用于治疗肿瘤的分次放射与sapc-dops的组合疗法
阅读说明:本技术 用于治疗肿瘤的分次放射与sapc-dops的组合疗法 (Combination therapy of fractionated radiation with SAPC-DOPS for the treatment of tumors ) 是由 X·齐 H·W·戴维斯 于 2018-10-16 设计创作,主要内容包括:提供了治疗有需要的患者的恶性实体瘤的方法,该方法包括向患者施用组合疗法,所述组合疗法包括:分次放射疗法和治疗有效量的鞘脂激活蛋白C(SapC)和二油酰基磷脂酰丝氨酸(SapC-DOPS),其中分次放射疗法包括多个放射部分,每个所述部分所递送的辐射剂量低于单独施用时有效抑制肿瘤生长的剂量。还提供了增强SapC-DOPS的抗肿瘤功效的方法。(There is provided a method of treating a malignant solid tumor in a patient in need thereof, the method comprising administering to the patient a combination therapy comprising: fractionated radiation therapy and therapeutically effective amounts of sphingolipid activating protein C (SapC) and dioleoylphosphatidylserine (SapC-DOPS), wherein the fractionated radiation therapy comprises a plurality of fractions of radiation, each of said fractions delivering a dose of radiation that is less than the dose effective to inhibit tumor growth when administered alone. Also provided are methods of enhancing the anti-tumor efficacy of SapC-DOPS.)
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