阅读说明：本技术 一种改善记忆障碍的磷脂组合物 (Phospholipid composition for improving dysmnesia ) 是由 严伟 代竟 彭长文 于 2020-05-29 设计创作，主要内容包括：本发明涉及一种改善记忆障碍的磷脂组合物。具体提供了一种磷脂组合物,它包含下述重量配比的组分：磷脂酰丝氨酸1～2份,大豆磷脂1～2份。该组合物能够显著改善小鼠记忆障碍；该组合物中磷脂酰丝氨酸与大豆磷脂组合使用对记忆障碍的改善发挥了协同增效作用,与单独使用大豆磷脂或磷脂酰丝氨酸相比,该组合物能够显著提高对记忆障碍的改善效果。本发明的组合物可以用来制备改善记忆障碍的药物或保健食品,应用前景广阔。(The invention relates to a phospholipid composition for improving dysmnesia. Particularly provides a phospholipid composition, which comprises the following components in parts by weight: 1-2 parts of phosphatidylserine and 1-2 parts of soybean phospholipid. The composition can remarkably improve memory disorder of mice; the composition has synergistic effect of phosphatidylserine and soybean phospholipid, and can improve dysmnesia compared with soybean phospholipid or phosphatidylserine alone. The composition can be used for preparing medicines or health-care foods for improving dysmnesia, and has wide application prospect.)

1. A phospholipid composition characterized by: the paint comprises the following components in parts by weight: 1-2 parts of phosphatidylserine and 1-2 parts of soybean phospholipid.

2. The phospholipid composition of claim 1 wherein: the paint comprises the following components in parts by weight: 1 part of phosphatidylserine and 1 part of soybean phospholipid.

3. The phospholipid composition of claim 2 wherein: the purity of the phosphatidylserine is 95 wt.% or more; and/or, the soybean phospholipid content is more than 93 wt.%.

4. A medicament or food for improving memory impairment, characterized in that: the medicine or food is prepared by taking the phospholipid composition as defined in any one of claims 1 to 3 as an active ingredient and adding pharmaceutically acceptable auxiliary materials or food auxiliary materials.

5. Use of a phospholipid composition according to any one of claims 1 to 3 in the manufacture of a medicament for improving memory disorders.

6. Use according to claim 5, characterized in that: the memory disorder is dementia, brain trauma, cerebral ischemia or memory disorder caused by stress.

7. Use according to claim 6, characterized in that: the dementia is senile dementia, vascular dementia or dementia with Lewy bodies.

8. A phosphatidylserine chocolate, comprising: the composition is prepared from the following raw materials in parts by weight: 30 parts of cocoa butter, 15-30 parts of cocoa liquid, 5-10 parts of cocoa powder, 0-25 parts of milk powder, 30-38 parts of sweetener, 1.0-2.0 parts of emulsifier and 0.3-0.5 part of spice; the emulsifier is a mixture of phosphatidylserine and soybean phospholipid, and the weight ratio of the phosphatidylserine to the soybean phospholipid is (1-2): (1-2).

9. The phosphatidylserine chocolate of claim 8, wherein: the weight ratio of the phosphatidylserine to the soybean phospholipid is 1: 1;

and/or the sweetener is selected from one or a mixture of more than two of sucrose, arabinose, oligosaccharide and sugar substitute; and/or the perfume is selected from one or a mixture of more than two of maltol, vanillin and ethyl vanillin; and/or the milk powder is whole milk powder.

10. Phosphatidylserine chocolate according to claim 8 or 9, wherein: the composition is prepared from the following raw materials in parts by weight: 30 parts of cocoa butter, 25-30 parts of cocoa liquor, 5-10 parts of cocoa powder, 25-30 parts of cane sugar, 8 parts of arabinose, 0.8 part of phosphatidylserine, 0.8 part of soybean phospholipid and 0.3-0.5 part of spice; or, it comprises the following raw materials by weight: 20 parts of cocoa butter, 15-20 parts of cocoa liquor, 5-10 parts of cocoa powder, 23-25 parts of milk powder, 30-35 parts of cane sugar, 0.8 part of phosphatidylserine, 0.8 part of soybean phospholipid and 0.3-0.5 part of spice;

preferably, the feed additive is prepared from the following raw materials in parts by weight: 30g of cocoa butter, 25g of cocoa liquor, 10g of cocoa powder, 25g of cane sugar, 8g of arabinose, 0.8g of phosphatidylserine, 0.8g of soybean phospholipid and 0.4g of spice; or, it comprises the following raw materials by weight: 20g of cocoa butter, 15g of cocoa liquor, 10g of cocoa powder, 23g of milk powder, 30g of cane sugar, 0.8g of phosphatidylserine, 0.8g of soybean phospholipid and 0.4g of spice.

Technical Field

The invention belongs to the field of medicine, and particularly relates to a phospholipid composition for improving dysmnesia.

Background

Dysmnesia refers to a state in which an individual cannot remember or recall information or skills, and clinical manifestations include impaired memory, amnesia, confusion, fictional and latent memory. Clinically, memory impairment is a syndrome in which many diseases can occur, such as dementia, alzheimer's disease, and the like. Dementia refers to chronic acquired progressive intellectual disorder syndrome, which is clinically characterized by slow-occurring intellectual decline, which is a core symptom and occurs at an early stage. With the acceleration of aging of the population, the incidence of senile dementia also increases, and the senile dementia becomes the fourth leading cause of death of the elderly after tumors, heart diseases and cerebrovascular diseases. Alzheimer's Disease (AD) is a progressive neurodegenerative disease characterized clinically by memory impairment, aphasia, apraxia, agnosia, impaired visuospatial function, etc., especially progressively aggravated intellectual memory impairment.

Causes of dysmnesia are complex, the common diseases at present are dementia (including senile dementia, vascular dementia or dementia with Lewy bodies), Alzheimer disease, brain trauma, cerebral ischemia or dysmnesia caused by stress, and the dysmnesia has serious influence on the normal life of patients. However, the western medicines have poor effect of treating dysmnesia so far, and patients often have obvious difference in reaction to certain specific medicines, and are easy to have drug resistance and side effects. Therefore, there is a need to develop a safe and effective new drug for treating dysmnesia.

Phosphatidylserine is also called composite nervonic acid, has the English name of Phosphatidylserine, is called PS for short, and can be extracted from natural soybean oil residues. Phosphatidylserine is an active substance of cell membranes, especially present in brain cells. The functional components mainly improve nerve cell function, regulate the conduction of nerve pulse and enhance brain memory function, and the lipophilic components can quickly enter the brain through a blood brain barrier after being absorbed due to strong lipophilicity, thereby playing the roles of relieving blood vessel smooth muscle cells and increasing blood supply of the brain.

Soy phospholipids are products extracted from the oil foot from the production of soybean oil, are esters of glycerol, fatty acids, choline or cholamine, and are soluble in oils and nonpolar solvents. The composition of soybean phospholipids mainly contains lecithin (about 34.2%), cephalin (about 19.7%), inositol phospholipid (about 16.0%), phosphatidylserine (about 15.8%), phosphatidic acid (about 3.6%) and other phospholipids (about 10.7%), as light yellow to brown viscous liquid or as white to light brown solid powder.

At present, there is no report of using phosphatidylserine in combination with soybean phospholipids to improve memory disorders.

Disclosure of Invention

The present invention aims to provide a phospholipid composition capable of significantly improving memory impairment.

The invention provides a phospholipid composition, which comprises the following components in parts by weight: 1-2 parts of phosphatidylserine and 1-2 parts of soybean phospholipid.

Further, the composition comprises the following components in parts by weight: 1 part of phosphatidylserine and 1 part of soybean phospholipid.

Further, the purity of the phosphatidylserine is 95 wt.% or more; and/or, the soybean phospholipid content is more than 93 wt.%.

The invention also provides a medicament or food for improving dysmnesia, which is prepared by taking the phospholipid composition as an active ingredient and adding pharmaceutically acceptable auxiliary materials or food auxiliary materials.

The invention also provides application of the phospholipid composition in preparing a medicament for improving dysmnesia.

Further, the memory disorder is dementia, brain trauma, brain ischemia, or memory disorder caused by stress.

Further, the dementia is senile dementia, vascular dementia or dementia with lewy bodies.

The invention also provides phosphatidylserine chocolate which is prepared from the following raw materials in parts by weight: 30 parts of cocoa butter, 15-30 parts of cocoa liquid, 5-10 parts of cocoa powder, 0-25 parts of milk powder, 30-38 parts of sweetener, 1.0-2.0 parts of emulsifier and 0.3-0.5 part of spice; the emulsifier is a mixture of phosphatidylserine and soybean phospholipid, and the weight ratio of the phosphatidylserine to the soybean phospholipid is (1-2): (1-2).

Further, the weight ratio of the phosphatidylserine to the soybean phospholipid is 1: 1;

and/or the sweetener is selected from one or a mixture of more than two of sucrose, arabinose, oligosaccharide and sugar substitute; and/or the perfume is selected from one or a mixture of more than two of maltol, vanillin and ethyl vanillin; and/or the milk powder is whole milk powder.

Further, the feed additive is prepared from the following raw materials in parts by weight: 30 parts of cocoa butter, 25-30 parts of cocoa liquor, 5-10 parts of cocoa powder, 25-30 parts of cane sugar, 8 parts of arabinose, 0.8 part of phosphatidylserine, 0.8 part of soybean phospholipid and 0.3-0.5 part of spice; or, it comprises the following raw materials by weight: 20 parts of cocoa butter, 15-20 parts of cocoa liquor, 5-10 parts of cocoa powder, 23-25 parts of milk powder, 30-35 parts of cane sugar, 0.8 part of phosphatidylserine, 0.8 part of soybean phospholipid and 0.3-0.5 part of spice;

preferably, the feed additive is prepared from the following raw materials in parts by weight: 30g of cocoa butter, 25g of cocoa liquor, 10g of cocoa powder, 25g of cane sugar, 8g of arabinose, 0.8g of phosphatidylserine, 0.8g of soybean phospholipid and 0.4g of spice; or, it comprises the following raw materials by weight: 20g of cocoa butter, 15g of cocoa liquor, 10g of cocoa powder, 23g of milk powder, 30g of cane sugar, 0.8g of phosphatidylserine, 0.8g of soybean phospholipid and 0.4g of spice.

The composition provided by the invention can obviously improve the memory disorder of mice; compared with the single use of soybean phospholipid or phosphatidylserine, the composition of the invention can obviously improve the improvement effect on dysmnesia. Therefore, in the composition of the present invention, the combination of phosphatidylserine and soybean phospholipid exerts a synergistic effect on the improvement of memory disorder. The composition can be used for preparing medicines or health-care foods for improving dysmnesia, and has wide application prospect.

The phosphatidylserine chocolate provided by the invention is bright and vivid in color, pure and mellow in fragrance, fine and smooth in taste, and also has an excellent effect of improving dysmnesia.

Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.

The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Detailed Description

The raw materials and equipment used in the invention are known products and are obtained by purchasing commercial products.

Wherein the phosphatidylserine is obtained from a commercial source, wherein the phosphatidylserine content is 95 wt.%.

The soybean phospholipids were obtained from commercial sources, and the content of soybean phospholipids was 93 wt.% based on acetone-insoluble matter, i.e., the content of phospholipids in soybean phospholipids was 93 wt.%. Phospholipids, also known as phospholipids or phospholipids, are lipids containing phosphoric acid and belong to complex lipids.