阅读说明：本技术 一种桑辛素n在制备抗肿瘤药物中的应用 (Application of morin N in preparation of antitumor drugs ) 是由 田景奎 高成成 李守信 袁婳婳 吴知盼 韩昊特 朱玮 于 2019-12-24 设计创作，主要内容包括：本发明属医药生物技术领域,涉及一种桑辛素N在制备抗肿瘤药物中的应用,特别是在肺癌的治疗药物中的用途。桑辛素N制备的肿瘤药物能够通过抑制肿瘤细胞的活力、抑制肿瘤细胞迁移、诱导肿瘤细胞凋亡等途径抑制肿瘤。(The invention belongs to the field of medical biotechnology, and relates to application of sangusin N in preparation of antitumor drugs, in particular to application in treatment of lung cancer. The tumor drug prepared from the morin N can inhibit tumors by inhibiting the activity of tumor cells, inhibiting the migration of the tumor cells, inducing the apoptosis of the tumor cells and the like.)

1. Application of sanguinarine N in preparing antitumor drugs is provided.

2. The use of sangusin N according to claim 1 in the preparation of an antitumor medicament, wherein: the tumor refers to lung cancer, colon cancer, prostatic cancer, gastric cancer, liver cancer, breast cancer and glioma.

3. The use of sangusin N according to claim 2 in the preparation of an antitumor medicament, wherein: the tumor refers to lung cancer.

4. The use of sangusin N according to claims 1-3 in the preparation of an antitumor medicament, characterized in that: the anti-tumor medicine is an oral preparation, an injection, an inhalation preparation or an external preparation.

Technical Field

The invention belongs to the field of biological medicines, and particularly relates to application of morin N in preparation of an anti-tumor medicine.

Background

Cancer is a serious public health problem in the world and is a risk factor which seriously affects the health of residents, the burden of cancer is in a continuously increasing situation in the world in the last decade, and about 800 million people die of cancer every year in the world according to data published by the international cancer research institution. The patients who die from cancer account for 1/4 of all causes of death in China, and are the first cause of death. The cancers seriously threatening the health of residents in China mainly comprise lung cancer, liver cancer, breast cancer, gastric cancer and the like. Due to various factors such as environmental pollution, aging population, and the wide existence of bad life style such as unhealthy diet, insufficient physical activity, smoking, alcoholism, obesity, etc., cancer in China is on the rise in the last decade. Therefore, the task of preventing and treating cancer is extremely difficult.

The invention discloses a method for inducing mulberry leaves to generate a secondary metabolite, which is characterized in that the content of the secondary metabolite is changed by the induction of mulberry leaves through UV-B, wherein the content of morocin N (CAS NO: 135248-05-4) is obviously increased.

Disclosure of Invention

The invention aims to provide application of morin N in preparation of antitumor drugs. The morin N can effectively inhibit the proliferation of tumor cells, inhibit the migration of the tumor cells and induce the tumor cells to undergo apoptosis.

The invention is realized by adopting the following technical scheme:

application of sanguinarine N in preparing antitumor drugs is provided.

In the above technical solution, preferably, the tumor includes the following tumors: lung cancer, colon cancer, prostatic cancer, gastric cancer, liver cancer, breast cancer, glioma, and morin N can be used for preparing the above medicines.

More preferably, the tumor is lung cancer.

Preferably, in the preparation of the antitumor drug, the morusin N is prepared into various clinically used drugs of different formulations, including various formulations such as injection, tablet, capsule, soft capsule, microcapsule, nano-formulation, granule, membrane, suppository, aerosol and the like, by a conventional preparation process, alone or in combination with other drugs.

The invention has the beneficial effects that:

the invention provides application of the morin N as an anti-tumor drug raw material or a potential drug, the morin N can play a role by multiple mechanisms of inhibiting the activity of tumor cells, inhibiting the migration of the tumor cells, inducing the apoptosis of the tumor cells and the like, and has better development potential.

Drawings

FIG. 1 shows the inhibition of the healing of A549 lung cancer cell scratch by morin N;

FIG. 2 shows the inhibition of the healing of scarification of PC-9 lung cancer cells by morin N;

FIG. 3 the effect of morin N on the apoptosis rate of A549 lung cancer cells;

FIG. 4 shows the effect of sanguinarine N on the apoptosis rate of PC-9 lung cancer cells.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, embodiments accompanying the present invention are further described below. The invention is not limited to the embodiments listed but also comprises any other known variations within the scope of the invention as claimed.

The invention relates to application of morin N in preparing antitumor drugs. In particular to the application in the pharmaceutical preparation of drugs for treating various tumors such as lung cancer, colon cancer, prostatic cancer, gastric cancer, liver cancer, breast cancer, glioma and the like. The invention also provides a method for preparing various clinically used medicaments in different dosage forms, including injections, tablets, capsules, soft capsules, microcapsules, nano preparations, granules, films, suppositories, aerosols and the like by using the morin N alone or in combination with other medicaments.