阅读说明：本技术 通过使用vlp复制子投递ii类mhc抗原的癌症免疫疗法 (Cancer immunotherapy by delivering class II MHC antigens using VLP replicons ) 是由 D.K.查特吉 S.J.卡茨玛茨克 于 2014-12-16 设计创作，主要内容包括：本文中描述的是预防或治疗哺乳动物受试者中疾病的方法,包括对有此需要的受试者施用有效剂量的药物组合物,其包含病毒样颗粒(VLP),该颗粒包含：包含重组多核苷酸的α病毒复制子,逆转录病毒gag蛋白,和促融合包膜蛋白,其中所述多核苷酸包含编码人II类主要组织相容性抗原的两个亚基的序列,其中所述VLP不含有α病毒结构蛋白基因。(Described herein is a method of preventing or treating a disease in a mammalian subject, comprising administering to a subject in need thereof an effective dose of a pharmaceutical composition comprising a virus-like particle (VLP) comprising: an alphavirus replicon comprising a recombinant polynucleotide, a retroviral gag protein, and a fusogenic envelope protein, wherein the polynucleotide comprises sequences encoding two subunits of a human class II major histocompatibility antigen, wherein the VLP does not contain an alphavirus structural protein gene.)