阅读说明：本技术 一种治疗肺动脉高压和相关性肺动脉高压的方法以及每日给药 (A method for treating pulmonary hypertension and related pulmonary hypertension and daily administration ) 是由 M·阿隆索-加力西亚 D·卡朋特 T·帕克 M·罗兹 J·鲁尔卡 S·灵 于 2020-03-13 设计创作，主要内容包括：存在一种治疗或预防患者肺动脉高压(PAH)或相关性肺动脉高压(APAH)的方法。所述方法含有向患者全身给予有效治疗量的以下一种或多种化合物的步骤：(S)-乙基8-(2-氨基-6-((R)-1-(5-氯-[1,1'-联苯]-2-基])-2,2,2-三氟乙氧基)嘧啶-4-基)-2,8-二氮杂螺[4.5]癸烷-3-羧酸盐或其药用盐,或(S)-8-(2-氨基-6-((R)-1-(5-氯-[1,1'-联苯]-2-基)-2,2,2-三氟乙氧基)嘧啶-4-基)-2,8-二氮杂螺[4.5]癸烷-3-羧酸或其药用盐,或前述的组合。还存在通过全身给予约1mg/kg/天至约50mg/kg/天有效治疗量的TPH1抑制剂来治疗或预防患者PAH或APAH的方法。存在一种以单一日剂量治疗患者PAH或APAH的方法。(There is a method of treating or preventing Pulmonary Arterial Hypertension (PAH) or Associated Pulmonary Arterial Hypertension (APAH) in a patient. The method comprises the step of systemically administering to the patient a therapeutically effective amount of one or more of the following compounds: (S) -Ethyl 8- (2-amino-6- ((R) -1- (5-chloro- [1,1' -biphenyl ] -2-yl ]) -2,2, 2-trifluoroethoxy) pyrimidin-4-yl) -2, 8-diazaspiro [4.5] decane-3-carboxylic acid salt or a pharmaceutically acceptable salt thereof, or (S) -8- (2-amino-6- ((R) -1- (5-chloro- [1,1' -biphenyl ] -2-yl) -2,2, 2-trifluoroethoxy) pyrimidin-4-yl) -2, 8-diazaspiro [4.5] decane-3-carboxylic acid or a pharmaceutically acceptable salt thereof, or a combination of the foregoing. Methods also exist for treating or preventing PAH or APAH in a patient by systemically administering a therapeutically effective amount of a TPH1 inhibitor from about 1 mg/kg/day to about 50 mg/kg/day. There is a method of treating PAH or APAH in a patient in a single daily dose.)