阅读说明：本技术 含硝羟喹啉的药物组合物、硝羟喹啉口服固体片剂及其制备方法和用途 (Pharmaceutical composition containing nitroxoline, nitroxoline oral solid tablet, and preparation method and application thereof ) 是由 刘江华 郭玉申 申帅 朱伟 于 2020-08-05 设计创作，主要内容包括：一种用于治疗膀胱癌的含硝羟喹啉的药物组合物、硝羟喹啉口服固体片剂及其制备方法和用途。所述药物组合物包含硝羟喹啉、填充剂、崩解剂、粘合剂和润滑剂；所述润滑剂选自十二烷基硫酸钠和硬脂富马酸钠中的一种或两种。所述的药物组合物,溶出速度适中,能够避免突释现象,防潮防渗透,稳定性好,安全有效,服用方便,患者顺应性强,满足了作为口服固体片剂的要求。所述的制备方法,生产工艺稳定,重现性好,易于大生产,具有较好的临床使用价值和社会效益。(A pharmaceutical composition containing nitroxoline for treating bladder cancer, oral solid tablet containing nitroxoline, and its preparation method and application are provided. The pharmaceutical composition comprises nitroxoline, a filler, a disintegrant, a binder and a lubricant; the lubricant is selected from one or two of sodium lauryl sulfate and sodium stearyl fumarate. The pharmaceutical composition has moderate dissolution speed, can avoid burst release phenomenon, is dampproof and impermeable, has good stability, safety and effectiveness, convenient administration and strong patient compliance, and meets the requirements of being taken as an oral solid tablet. The preparation method has the advantages of stable production process, good reproducibility, easy mass production, and good clinical use value and social benefit.)