阅读说明：本技术 一种复方酚咖伪麻胶囊生产工艺 (Production process of compound paracetamol, caffeine and pseudoephedrine capsules ) 是由 张作 向杨 于 2021-03-22 设计创作，主要内容包括：本发明公开了一种复方酚咖伪麻胶囊生产工艺,包括如下步骤：S1、将复方酚咖伪麻胶囊的四种辅料进行粉碎,然后过筛80目,按批用量分零后退回库房备用；S2、将对乙酰氨基酚、咖啡因、盐酸伪麻黄碱、马来酸氯苯那敏、盐酸氯哌丁、硬脂酸镁在80℃±5℃的温度下,分别用热风循环烘箱干燥4小时备用；S3、将对乙酰氨基酚、咖啡因、盐酸伪麻黄碱、马来酸氯苯那敏、盐酸氯哌丁、硬脂酸镁和菠萝蛋白酶按处方称取后投入混合机中混合20分钟,中间产品检验合格后开始充填,在充填完毕后铝塑包装,最后外包装,检验合格后即为成品入库。本发明制得的复方酚咖伪麻胶囊能有效地治疗炎症和水肿,从提高自身免疫力入手,增强人体的抵抗力。(The invention discloses a production process of a compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule, which comprises the following steps: s1, crushing the four auxiliary materials of the compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule, sieving by a 80-mesh sieve, dividing the amount into zero according to the batch amount, and returning the mixture to a storehouse for later use; s2, drying acetaminophen, caffeine, pseudoephedrine hydrochloride, chlorphenamine maleate, cloperamide hydrochloride and magnesium stearate in a hot air circulation oven at the temperature of 80 +/-5 ℃ for 4 hours for later use; s3, weighing acetaminophen, caffeine, pseudoephedrine hydrochloride, chlorphenamine maleate, cloperastine hydrochloride, magnesium stearate and bromelain according to the prescription, putting into a mixing machine, mixing for 20 minutes, filling after the intermediate product is qualified, carrying out aluminum-plastic packaging after filling, finally carrying out external packaging, and warehousing the finished product after the intermediate product is qualified. The compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule prepared by the invention can effectively treat inflammation and edema, starts from improving the autoimmunity and enhances the resistance of a human body.)

1. A production process of a compound paracetamol, caffeine and pseudoephedrine capsule is characterized by comprising the following steps: the method comprises the following steps:

s1, crushing the four auxiliary materials of the compound paracetamol, caffeine, pseudoephedrine hydrochloride, chlorphenamine maleate and cloperamide hydrochloride, sieving by a 80-mesh sieve, and returning to a storehouse for later use after being divided into zero according to the batch amount;

s2, taking all caffeine, pseudoephedrine hydrochloride, chlorpheniramine maleate and cloperastine hydrochloride produced in the current batch, controlling the humidity of acetaminophen, caffeine, pseudoephedrine hydrochloride, chlorpheniramine maleate, cloperastine hydrochloride and magnesium stearate at the temperature of 80 +/-5 ℃ and 45-65%, and respectively drying for 4 hours by a hot air circulation oven for later use;

s3, weighing acetaminophen, caffeine, pseudoephedrine hydrochloride, chlorphenamine maleate, cloperastine hydrochloride, magnesium stearate and bromelain according to the prescription, putting into a mixing machine, mixing for 20 minutes, filling after the intermediate product is qualified, carrying out aluminum-plastic packaging after filling, finally carrying out external packaging, and warehousing the finished product after the intermediate product is qualified.

2. The production process of the compound paracetamol, caffeine and pseudoephedrine capsule according to claim 1, is characterized in that: the compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule comprises the following raw materials in parts by weight: 150mg of acetaminophen, 12.5mg of caffeine, 15mg of pseudoephedrine hydrochloride, 1.25mg of chlorpheniramine maleate, 6mg of cloperastine hydrochloride, 1.6 ten thousand units of bromelain and 5mg of magnesium stearate.

3. The production process of the compound paracetamol, caffeine and pseudoephedrine capsule according to claim 1, is characterized in that: the error of the two weighing in the step S1 is 1-2 percent, namely the product is qualified; before step S1, the cleanliness of production equipment needs to be checked, and the production operation can be carried out after the cleanliness meets the requirements; the production equipment comprises a high-efficiency crusher, a hot air circulation oven, a multidirectional motion mixer, a full-automatic capsule filling machine, a high-speed aluminum-plastic blister packaging machine, a multifunctional full-automatic high-speed pillow type packaging machine, a horizontal full-automatic box packing machine, an online weight scale, a transparent film three-dimensional packaging machine, a laser code spraying machine, an electronic management code system and a high-platform bundling machine.

Technical Field

The invention belongs to the technical field of capsule production, and particularly relates to a production process of a compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule.

Background

Generally, influenza is mostly manifested in the respiratory tract system, most people can recover themselves within two days to one week, but for the elderly and patients with chronic diseases, because of low autoimmunity, complications such as bronchitis, pneumonia and meningitis are easy to occur and even death is easy to occur due to bacterial infection.

The existing treatment method mainly adopts western medicine treatment, but many medicines for treating cold belong to antibiotic medicines, and are extremely harmful to people. Mainly, it has high incidence and wide influence range, can often cause complications such as nasosinusitis, pharyngolaryngitis, bronchitis or pneumonia, and can cause acute attack of chronic bronchitis. Is a common disease seriously harming human health. Bromelain has an anti-inflammatory effect, can effectively treat inflammation and edema in various tissues, and has the potential of activating inflammatory reaction. Therefore, a production process of the compound paracetamol, caffeine and pseudoephedrine capsule is provided to solve the problems mentioned in the background technology.

Disclosure of Invention

The invention aims to provide a production process of a compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule, which aims to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: a production process of a compound paracetamol, caffeine and pseudoephedrine capsule comprises the following steps:

s1, crushing the four auxiliary materials of the compound paracetamol, caffeine, pseudoephedrine hydrochloride, chlorphenamine maleate and cloperamide hydrochloride, sieving by a 80-mesh sieve, and returning to a storehouse for later use after being divided into zero according to the batch amount;

s2, taking all caffeine, pseudoephedrine hydrochloride, chlorpheniramine maleate and cloperastine hydrochloride produced in the current batch, controlling the humidity of acetaminophen, caffeine, pseudoephedrine hydrochloride, chlorpheniramine maleate, cloperastine hydrochloride and magnesium stearate at the temperature of 80 +/-5 ℃ and 45-65%, and respectively drying for 4 hours by a hot air circulation oven for later use;

s3, weighing acetaminophen, caffeine, pseudoephedrine hydrochloride, chlorphenamine maleate, cloperastine hydrochloride, magnesium stearate and bromelain according to the prescription, putting into a mixing machine, mixing for 20 minutes, filling after the intermediate product is qualified, carrying out aluminum-plastic packaging after filling, finally carrying out external packaging, and warehousing the finished product after the intermediate product is qualified.

The compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule comprises the following raw materials in parts by weight: 150mg of acetaminophen, 12.5mg of caffeine, 15mg of pseudoephedrine hydrochloride, 1.25mg of chlorpheniramine maleate, 6mg of cloperastine hydrochloride, 1.6 ten thousand units of bromelain and 5mg of magnesium stearate.

The error of the two weighing in the step S1 is 1-2 percent, namely the product is qualified; before step S1, the cleanliness of production equipment needs to be checked, and the production operation can be carried out after the cleanliness meets the requirements; the production equipment comprises a high-efficiency crusher, a hot air circulation oven, a multidirectional motion mixer, a full-automatic capsule filling machine, a high-speed aluminum-plastic blister packaging machine, a multifunctional full-automatic high-speed pillow type packaging machine, a horizontal full-automatic box packing machine, an online weight scale, a transparent film three-dimensional packaging machine, a laser code spraying machine, an electronic management code system and a high-platform bundling machine.

Compared with the prior art, the invention has the beneficial effects that: compared with the traditional technology, the production process of the compound paracetamol, caffeine, pseudoephedrine and pseudoephedrine hydrochloride capsule provided by the invention is simple, can regulate the nervous system of a human body through western medicine components in the capsule to relieve pain and fever, relieve cough and asthma, relieve nasal obstruction, sore throat and other symptoms, can effectively treat inflammation and edema in various tissues by adding bromelain, starts with improvement of autoimmunity, enhances the resistance of the human body, has no dependence on the human body, and recuperates the symptoms of weakness, frequent dizziness and cold to a normal state. The raw materials are crushed and dried, so that the mixing uniformity is ensured, and the produced capsule has high surface smoothness, small weight difference and high qualification rate.

Drawings

Fig. 1 is a schematic flow diagram of a production process of a compound paracetamol, caffeine and pseudoephedrine capsule.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1: the invention provides a production process of a compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule as shown in figure 1, which comprises the following steps:

s1, crushing the four auxiliary materials of the compound paracetamol, caffeine, pseudoephedrine hydrochloride, chlorphenamine maleate and cloperamide hydrochloride, sieving by a 80-mesh sieve, and returning to a storehouse for later use after being divided into zero according to the batch amount;

s2, taking all caffeine, pseudoephedrine hydrochloride, chlorpheniramine maleate and cloperastine hydrochloride produced in the current batch, controlling the humidity of acetaminophen, caffeine, pseudoephedrine hydrochloride, chlorpheniramine maleate, cloperastine hydrochloride and magnesium stearate at the temperature of 80 +/-5 ℃ and 45-65%, and respectively drying for 4 hours by a hot air circulation oven for later use;

s3, weighing acetaminophen, caffeine, pseudoephedrine hydrochloride, chlorphenamine maleate, cloperastine hydrochloride, magnesium stearate and bromelain according to the prescription, putting into a mixing machine, mixing for 20 minutes, filling after the intermediate product is qualified, carrying out aluminum-plastic packaging after filling, finally carrying out external packaging, and warehousing the finished product after the intermediate product is qualified.

The compound paracetamol, caffeine and pseudoephedrine hydrochloride capsule comprises the following raw materials in parts by weight: 150mg of acetaminophen, 12.5mg of caffeine, 15mg of pseudoephedrine hydrochloride, 1.25mg of chlorpheniramine maleate, 6mg of cloperastine hydrochloride, 1.6 million units of bromelain and a proper amount of magnesium stearate.

The error of the two weighing in the step S1 is 1-2 percent, namely the product is qualified; before step S1, the cleanliness of production equipment needs to be checked, and the production operation can be carried out after the cleanliness meets the requirements; the production equipment comprises a high-efficiency crusher, a hot air circulation oven, a multidirectional motion mixer, a full-automatic capsule filling machine, a high-speed aluminum-plastic blister packaging machine, a multifunctional full-automatic high-speed pillow type packaging machine, a horizontal full-automatic box packing machine, an online weight scale, a transparent film three-dimensional packaging machine, a laser code spraying machine, an electronic management code system and a high-platform bundling machine.

In conclusion, compared with the prior art, the method is simple, the western medicine components in the method can be used for regulating the nervous system of a human body to relieve pain and fever, relieve cough and asthma, relieve nasal obstruction, sore throat and other symptoms, the bromelain is added, inflammation and edema can be effectively treated in various tissues, the immunity of the human body is improved, the resistance of the human body is enhanced, the human body has no dependence, and the symptoms of weakness, frequent dizziness and cold are regulated to be in a normal state. The raw materials are crushed and dried, so that the mixing uniformity is ensured, and the produced capsule has high surface smoothness, small weight difference and high qualification rate.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.