阅读说明：本技术 治疗癫痫、发作和cns疾病的经口抗炎肽 (Oral anti-inflammatory peptides for the treatment of epilepsy, seizures and CNS disorders ) 是由 迈克尔·鲁夫 于 2019-07-09 设计创作，主要内容包括：治疗个体中的发作、癫痫或脑功能丧失的方法,包括制备包含全-D氨基酸肽和药学上可接受的载体的组合物的步骤。D肽具有一般结构：A-B-C-D-E,其中A是Ser、Thr、Asn、Glu、Ile。B是Ser、Thr、Asp、Asn,C是Thr、Ser、Asn、Arg、Lys、Trp,D是Tyr,并且E是Thr、Ser、Arg、Gly。并且其中D肽中的所有氨基酸都是D立体异构构型,并且所述肽组合物以治疗有效剂量施用,其中所述组合物起抑制脑功能丧失背后的炎症的作用。D肽可以在E处酯化、糖基化或酰胺化,以通过促进从循环中流出和渗透到脑中来增强组织分布。(A method of treating seizures, epilepsy, or loss of brain function in an individual comprising the step of preparing a composition comprising a all-D amino acid peptide and a pharmaceutically acceptable carrier. The D peptide has the general structure: A-B-C-D-E, wherein A is Ser, Thr, Asn, Glu, Ile. B is Ser, Thr, Asp, Asn, C is Thr, Ser, Asn, Arg, Lys, Trp, D is Tyr, and E is Thr, Ser, Arg, Gly. And wherein all of the amino acids in the D peptide are in the D stereoisomeric configuration, and said peptide composition is administered in a therapeutically effective dose, wherein said composition acts to inhibit inflammation following loss of brain function. The D peptide may be esterified, glycosylated, or amidated at E to enhance tissue distribution by facilitating efflux from the circulation and penetration into the brain.)