阅读说明：本技术 用于治疗房性心律失常的task-1抑制剂 (TASK-1 inhibitors for the treatment of atrial arrhythmias ) 是由 康斯坦丝·施密特 沃尔特·埃米尔·黑费利 雨果·卡图斯 尼尔斯·德凯尔 菲力克斯·维德曼 于 2019-08-14 设计创作，主要内容包括：本发明涉及具有式(I)所示结构的化合物或其药学上可接受的盐或前药,其用于治疗和/或预防对象的房性心律失常,其中R～1是乙基、-H或甲基,并且R～2是具有式(II)所示结构的侧链,其中X～1为C＝O、CH-2、C＝S、C-OH、C-NH-2或C-NO-2,X～2至X～4独立地选自CH-2、C＝O、C＝S、C-OH和C-NH-2或R～2为-NH-2。本发明还涉及与所述化合物有关的药物组合物和试剂盒。(The present invention relates to compounds having the structure shown in formula (I) or pharmaceutically acceptable salts or prodrugs thereof, which are used for treating and/or preventing atrial arrhythmia of a subject, wherein R 1 Is ethyl, -H or methyl, and R 2 Is a side chain having a structure represented by the formula (II) wherein X 1 Is C-O, CH 2 、C＝S、C‑OH、C‑NH 2 Or C-NO 2 ，X 2 To X 4 Independently selected from CH 2 C-O, C-S, C-OH and C-NH 2 Or R 2 is-NH 2 . The invention also relates to a method for producing the samePharmaceutical compositions and kits related to the compounds.)