阅读说明：本技术 5’-核苷酸或其混合物在制备改善衰老细胞代谢的药物或功能食品中的应用 (Application of 5' -nucleotide or mixture thereof in preparing medicine or functional food for improving metabolism of senescent cells ) 是由 李勇 珠娜 徐美虹 陈玉松 于 2021-07-30 设计创作，主要内容包括：本发明涉及5’-核苷酸或其混合物在制备改善衰老细胞代谢的药物或功能食品中的应用。本发明所述5’-核苷酸是以核糖核酸为原料经酶法降解生产的,纯度在99％以上的5’-单磷酸腺苷、5’-单磷酸胞苷、5’-鸟苷酸二钠、5’-尿苷酸二钠或5’-肌苷酸二钠,其混合物中各核苷酸有效百分含量以CMP、AMP、UMP、GMP、IMP分子计分别为：CMP 23-78％、AMP 6-44％、UMP 7-40％、GMP 7-51％、IMP为0、或大于0且不高于2.5％。本发明发现,5’-核苷酸或其混合物具有预防和治疗细胞周期阻滞、增加NAD～(+)和/或L-谷氨酰胺含量、增强细胞代谢水平的作用。(The invention relates to the use of 5' -nucleotides or mixtures thereof for the preparation of a medicament or functional food for improving the metabolism of senescent cells. The 5 '-nucleotide is produced by taking ribonucleic acid as a raw material and degrading the ribonucleic acid by an enzyme method, and the purity of the 5' -adenosine monophosphate, the 5 '-cytidine monophosphate and the 5' -guanylic acid dinucleotide is more than 99 percentSodium, disodium 5 '-uridylate or disodium 5' -inosinate, wherein the effective percentage content of each nucleotide in the mixture is respectively as follows according to the molecular weight of CMP, AMP, UMP, GMP and IMP: CMP 23-78%, AMP 6-44%, UMP 7-40%, GMP 7-51%, IMP 0, or greater than 0 and not greater than 2.5%. The invention discovers that 5' -nucleotide or mixture thereof has the functions of preventing and treating cell cycle retardation and increasing NAD + And/or L-glutamine content, enhancing the level of cellular metabolism.)