阅读说明：本技术 通过不对称氢化连续制备光学活性羰基化合物 (Continuous production of optically active carbonyl compounds by asymmetric hydrogenation ) 是由 P·策纳 O·贝 于 2019-09-03 设计创作，主要内容包括：通过在具有至少一个手性配体的均相铑催化剂存在下用氢气将前手性α,β-不饱和羰基化合物不对称氢化而连续生产光学活性羰基化合物的方法,其中在第一返混式反应器中对包含前手性α,β-不饱和羰基化合物的液体反应混合物施以气/液两相氢化,和液体反应混合物随后在第二反应器中进一步氢化,其中所述前手性α,β-不饱和羰基化合物在第一反应器中以3重量％至20重量％的浓度使用。所述方法能够实现前手性α,β-不饱和羰基化合物的高总转化率。(A process for the continuous production of optically active carbonyl compounds by asymmetric hydrogenation of prochiral alpha, beta-unsaturated carbonyl compounds with hydrogen in the presence of a homogeneous rhodium catalyst having at least one chiral ligand, wherein a liquid reaction mixture comprising the prochiral alpha, beta-unsaturated carbonyl compounds is subjected to a gas/liquid two-phase hydrogenation in a first back-mixed reactor, and the liquid reaction mixture is subsequently further hydrogenated in a second reactor, wherein the prochiral alpha, beta-unsaturated carbonyl compounds are used in a concentration of from 3% to 20% by weight in the first reactor. The process enables high overall conversion of prochiral alpha, beta-unsaturated carbonyl compounds.)