阅读说明：本技术 排他地由设计者药物激活的设计者受体在治疗癫痫发作紊乱中的用途 (Use of designer receptors activated exclusively by designer drugs in the treatment of seizure disorders ) 是由 马修·杜林 于 2018-03-15 设计创作，主要内容包括：提供了用于治疗癫痫发作紊乱的方法和组合物,所述方法和组合物包括向患者施用编码修饰的受体的载体,用于将修饰的受体递送至靶位置,该修饰的受体被修饰以被合成配体激活,其中修饰的受体在被激活时抑制神经元放电；以及向患者施用合成配体。还提供了用于治疗需要其的患者中的癫痫发作紊乱的方法和组合物,所述方法和组合物通过向患者施用编码修饰的受体的载体,用于将修饰的受体递送至靶位置,该修饰的受体被修饰以被合成配体激活,其中修饰的受体在被激活时增加神经元放电；以及向患者施用合成配体。所述方法用于改善或减轻癫痫发作紊乱的一种或更多种症状。(Methods and compositions are provided for treating seizure disorders, the methods and compositions comprising administering to a patient a vector encoding a modified receptor, the modified receptor modified to be activated by a synthetic ligand, for delivering the modified receptor to a target location, wherein the modified receptor, when activated, inhibits neuronal discharge; and administering the synthetic ligand to the patient. Also provided are methods and compositions for treating seizure disorders in a patient in need thereof by administering to the patient a vector encoding a modified receptor, the modified receptor modified to be activated by a synthetic ligand, for delivering the modified receptor to a target location, wherein the modified receptor increases neuronal discharge when activated; and administering the synthetic ligand to the patient. The methods are useful for ameliorating or alleviating one or more symptoms of a seizure disorder.)