阅读说明：本技术 用于测定聚合物序列的方法 (Method for determining polymer sequence ) 是由 卡莱夫·G·布朗 蒂莫西·L·马辛厄姆 斯图尔特·W·瑞德 于 2019-09-04 设计创作，主要内容包括：本发明涉及一种测定靶聚合物或其部分的序列的方法,所述靶聚合物或其部分包括聚合物单元,所述聚合物单元包括典型聚合物单元和非典型聚合物单元。所述方法包括获取与所述靶聚合物相关的信号的一系列测量结果,其中所述信号的测量结果取决于多个聚合物单元,并且其中所述靶聚合物的所述聚合物单元调制所述信号,并且其中非典型聚合物单元与对应典型聚合物单元不同地调制所述信号。使用机器学习技术分析所述一系列测量结果,所述机器学习技术将非典型聚合物单元的测量结果归属于相应的对应典型聚合物单元的测量结果。根据经过分析的一系列测量结果测定所述靶聚合物或其部分的序列。可以另外地或可替代地测定从所述分析中鉴定的非典型聚合物单元。可以使用两种或更多种类型的非典型聚合物单元,所述两种或更多种类型的非典型聚合物单元与两种或更多种类型的典型聚合物单元相对应。多核苷酸可以是DNA。(The present invention relates to a method of determining the sequence of a target polymer or a portion thereof comprising polymer units including typical polymer units and atypical polymer units. The method includes obtaining a series of measurements of a signal associated with the target polymer, wherein the measurements of the signal depend on a plurality of polymer units, and wherein the polymer units of the target polymer modulate the signal, and wherein atypical polymer units modulate the signal differently than corresponding typical polymer units. The series of measurements are analyzed using a machine learning technique that attributes the measurements of atypical polymer units to the measurements of corresponding typical polymer units. Determining the sequence of the target polymer or portion thereof based on the analyzed series of measurements. Atypical polymer units identified from the analysis may additionally or alternatively be determined. Two or more types of atypical polymer units corresponding to two or more types of typical polymer units may be used. The polynucleotide may be DNA.)