阅读说明：本技术 疫苗组合物 (Vaccine composition ) 是由 苏米·比斯瓦斯 金菁 丽贝卡·爱丽丝·达布斯 吉纳维芙·玛丽·凯瑟琳·拉贝 于 2019-05-03 设计创作，主要内容包括：本发明涉及疫苗组合物,最特别地是其中抗原组分大(例如超过50kDa)的疫苗组合物,或是多聚体(即由亚单位组成)的疫苗组合物。这样的抗原组分特别令人感兴趣,因为它们可能代表来自目前无法针对其接种疫苗的病原体的抗原组分。本发明涉及包含展示抗原组分的粒子的组合物,其中所述组合物包含含有第一肽标签的抗原组分和含有第二肽标签的部分,其中所述抗原组分和所述部分通过所述第一和第二肽标签之间的异肽键连接,并且其中所述抗原组分超过50kDa,或者可选地是多聚体。(The present invention relates to vaccine compositions, most particularly vaccine compositions in which the antigenic component is large (e.g. over 50kDa), or multimeric (i.e. composed of subunits). Such antigenic components are of particular interest as they may represent antigenic components from pathogens for which vaccination is currently not possible. The present invention relates to a composition comprising a particle displaying an antigenic component, wherein said composition comprises an antigenic component comprising a first peptide tag and a moiety comprising a second peptide tag, wherein said antigenic component and said moiety are linked by an isopeptide bond between said first and second peptide tags, and wherein said antigenic component is more than 50kDa, or alternatively is a multimer.)