阅读说明：本技术 一种微生物消杀组合物及其制备方法 (Microbial killing composition and preparation method thereof ) 是由 张涛 王立 黄耀 于 2020-08-14 设计创作，主要内容包括：本发明公开了一种微生物消杀组合物及其制备方法,该组合物包含胍类消毒剂和阳离子表面活性剂、辅以润肤剂、起泡剂、pH调节剂等,但不含有乙醇。本发明的组合物不仅对于化脓性球菌、肠道致病菌、致病性酵母菌和医院感染常见细菌等的杀菌效果较好,并且对包膜冠状病毒亦具有杀灭作用。(The invention discloses a microbial sterilizing composition and a preparation method thereof, wherein the composition comprises a guanidine disinfectant, a cationic surfactant, an auxiliary emollient, a foaming agent, a pH regulator and the like, but does not contain ethanol. The composition has good sterilization effect on pyococcus, intestinal pathogenic bacteria, pathogenic yeast, hospital infection common bacteria and the like, and also has a killing effect on enveloped coronavirus.)

1. A microbial disinfectant composition comprising a guanidine disinfectant and a cationic surfactant, but no ethanol.

2. A biocidal composition according to claim 1 further comprising one or more of emollients, sudsing agents and pH modifiers.

3. A disinfecting composition as claimed in claim 1 or claim 2, wherein the guanidine disinfectant is selected from one or more of chlorhexidine gluconate, chlorhexidine, polyhexamethylene guanidine and salts thereof.

4. A disinfecting composition according to claim 1 or claim 2 wherein the cationic surfactant is selected from one or more of didecylammonium dichloride or a derivative thereof, benzalkonium chloride and benzalkonium bromide.

5. A disinfecting composition according to claim 2, wherein the emollient is selected from one or more of propylene glycol, glycerol and polyoxyethylene glycerol ether.

6. A biocidal composition according to claim 2 wherein the sudsing agent is selected from one or more of undecyl formamide propyl trimethyl ammonium sulphate, cocamidopropyl betaine and fatty amidopropyl amine oxide.

7. The disinfectant composition according to claim 2, wherein the pH adjusting agent is selected from one or more of lactic acid, citric acid, tartaric acid and malic acid.

8. A composition according to claim 1 or 2, having a pH of 4.0-6.0.

9. A biocidal composition according to claim 2 comprising:

。

10. the biocidal composition of claim 9 comprising:

11. a process for preparing a microbiocidal composition according to claims 1-10, comprising the steps of:

(1) adding water soluble emollient 90-95 wt% of the total amount of the above components, and stirring to dissolve completely;

(2) adding a guanidine disinfectant and a cationic surfactant into the mixed solution obtained in the step (1), and stirring until the guanidine disinfectant and the cationic surfactant are completely dissolved;

(3) adding a foaming agent into the mixed solution obtained in the step (2), and stirring until the foaming agent is completely dissolved;

(4) and (4) adding the residual amount of water into the step (3), mixing, and adding a pH regulator to regulate the pH of the mixed solution to 4.0-6.0 to obtain the water-soluble organic silicon dioxide.

12. Use of a microbiocidal composition according to claims 1-10 in the manufacture of a medicament for killing and controlling pyogenic cocci, enteropathogenic bacteria, pathogenic yeasts and common bacteria of nosocomial infections.

13. Use of a microbiocidal composition according to claims 1-10 in the manufacture of a medicament for killing and controlling structurally similar viruses such as human coronavirus, rotavirus, coronavirus and the like.

Technical Field

The invention belongs to the technical field of microbial killing, and particularly relates to a microbial killing composition and a preparation method thereof.

Background

Currently, there are no exact effective therapeutic drugs and vaccines against the new coronavirus of 2019. The treatment is mainly to support symptomatic and moderate suppression immunity. How to effectively block the transmission of viruses and establishing daily protection consciousness is a very effective preventive measure. An antiviral microbial killing composition can effectively block or reduce the risk of contact transmission and has important significance in protecting the health of people.

The disinfectant is mainly a composition of alcohols, disinfectant, surfactant, foaming agent, etc. The common disinfectant is guanidine disinfectant, and has stable property, good sterilizing effect and low irritation. In the prior art, chlorhexidine acetate and ethanol are used in a matching way, for example, the foam disinfectant disclosed by the invention patent with the application publication number of CN105456548A and the preparation process thereof, and the foam disinfectant comprises 0.05-0.5% of chlorhexidine acetate, 8-15% of glycerol, 50-75% of ethanol, 0.1-2% of cocobetaine and the like. Patent publications WO/2004/018003 (ALDAPHARMACEUTICAL CORP.), WO/1995/012395 (E.R. SQUIBB AND SONS, INC.) disclose the use of chlorhexidine gluconate for disinfection AND sterilization. In the prior art, didecyl ammonium dichloride and ethanol are used in combination. The invention discloses a skin disinfectant disclosed in the patent publication No. CN104337802A, which comprises 1-5 parts of didecylammonium dichloride, 2-10 parts of isopropyl myristate, 40-60 parts of ethanol, 1-2 parts of chlorhexidine, 2-4 parts of isopropanol and 50-80 parts of water. In addition, numerous patents have disclosed the use of didecylammonium dichloride for disinfection and sterilization, such as CN101492632B, CN1425286A, and the like.

Disclosure of Invention

The invention aims to provide a microbial sterilizing composition and a preparation method thereof, and the composition not only overcomes the defect of the prior art that the disinfectant has a virus killing effect, but also overcomes the obvious defects of irritation, safety and the like of ethanol in the prior art.

The invention relates to a microbial sterilizing composition, which comprises a guanidine disinfectant and a cationic surfactant, but does not contain ethanol.

The disinfectant composition of the present invention further comprises one or more of an emollient, a foaming agent and a pH adjusting agent

The guanidine disinfectant is selected from one or more of chlorhexidine gluconate, chlorhexidine, polyhexamethylene guanidine and salts thereof;

the disinfecting composition, wherein the cationic surfactant is one or more selected from didecyl ammonium dichloride or a derivative thereof, benzalkonium chloride and benzalkonium bromide; the emollient is selected from one or more of propylene glycol, glycerol and glycerol polyoxyethylene ether;

the foaming agent is selected from one or more of undecyl formamide propyl trimethyl ammonium sulfate, cocamidopropyl betaine and fatty amidopropyl amine oxide; the pH regulator is selected from one or more of lactic acid, citric acid, tartaric acid and malic acid,

the pH value is 4.0-6.0.

In one embodiment, preferably, the present invention provides a biocidal composition comprising:

more preferably, the present invention provides a biocidal composition comprising:

in the above preferred embodiment, the appropriate amount of the pH regulator is an amount to adjust the pH of the composition to 4.0-6.0.

The present invention also provides a method of preparing the microbial microbiocidal composition of the present invention, comprising the steps of:

(1) adding water soluble emollient 90-95 wt% of the total amount of the above components, and stirring to dissolve completely;

(2) adding a guanidine disinfectant and a cationic surfactant into the mixed solution obtained in the step (1), and stirring until the guanidine disinfectant and the cationic surfactant are completely dissolved;

(3) adding a foaming agent into the mixed solution obtained in the step (2), and stirring until the foaming agent is completely dissolved;

(4) and (4) adding the residual amount of water into the step (3), mixing, and adding a pH regulator to regulate the pH of the mixed solution to 4.0-6.0 to obtain the water-soluble organic silicon dioxide.

The invention also provides the application of the microbial sterilizing composition in the preparation of medicaments for killing and controlling pyogenic cocci, intestinal pathogenic bacteria, pathogenic yeast and common bacteria infected in hospitals.

The invention also provides the application of the microbial sterilizing composition in the preparation of medicaments for killing and preventing human coronavirus, rotavirus, coronavirus and the like with similar structures.

In a specific embodiment, the present invention provides a microbial disinfectant composition comprising the following components in percentage by weight:

in the above embodiments, the microbial disinfectant composition of the present invention, preferably, the guanidine disinfectant is one or more of chlorhexidine gluconate, chlorhexidine, polyhexamethylene guanidine and salts thereof, preferably chlorhexidine gluconate;

preferably, the cationic surfactant is one or more of didecyl ammonium dichloride and derivatives thereof, benzalkonium chloride and benzalkonium bromide, and is preferably didecyl ammonium dichloride;

preferably, the emollient is one or more of propylene glycol, glycerol and glycerol polyoxyethylene ether, and is preferably propylene glycol;

preferably, the foaming agent is one or more of undecyl formamide propyl trimethyl ammonium sulfate, cocamidopropyl betaine and fatty amide propyl amine oxide, and the foaming agent is preferably undecyl formamide propyl trimethyl ammonium sulfate;

preferably, the pH regulator of the composition is lactic acid and has a pH value of 4.0-6.0.

Compared with the prior art, the microbial sterilizing composition has the following advantages:

(1) the hand drying agent adopts purified water as a solvent, does not contain ethanol, has the characteristics of mildness and no stimulation, has better use tolerance and safety, and has higher drying speed and more comfortable and comfortable hand after drying. The microbial sterilizing composition contains an emollient, can protect hands of medical workers, and can prevent hand dryness or chapping caused by frequent use;

(2) the preparation method of the microbial sterilizing composition is simple and easy to operate, and the production cost is low. The guanidine disinfectant is adopted, so that the solubility of the guanidine disinfectant in water is high, the application range is wide, the disinfection effect and the bacteriostatic effect are strong under low concentration, the bacteriostatic time is long, and the effective bactericidal time can be prolonged;

(3) the guanidine disinfectant is matched with the cationic surfactant for use, and even if the guanidine disinfectant is not matched with ethanol for use, the guanidine disinfectant has a good effect of killing bacteria and viruses. The disinfectant can kill Escherichia coli, Staphylococcus aureus, and Candida albicans within 1min, and human coronavirus within 3min, and has high sterilizing speed and effect in killing human coronavirus compared with disinfectant in the prior art.

The specific implementation mode is as follows:

the present invention will be further described with reference to the following examples.