阅读说明：本技术 一种儿童湿疹药膏及其制备方法 (Children eczema ointment and preparation method thereof ) 是由 徐大伟 于 2020-07-14 设计创作，主要内容包括：本发明公开了一种儿童湿疹药膏及其制备方法,属于湿疹药物领域。本发明提供的一种儿童湿疹药膏,硝酸咪康唑能够抑制真菌细胞膜的合成,灭杀真菌,各药物成分相互配合,共同起到止痒、消炎、抑菌杀菌的作用,尤对真菌性感染、湿疹感染有明显效果,且使用安全无刺激,适用于儿童外服。(The invention discloses a children eczema ointment and a preparation method thereof, and belongs to the field of eczema medicines. The miconazole nitrate can inhibit the synthesis of fungal cell membranes and kill fungi, all the medicinal components are matched with each other, so that the ointment for treating the eczema provided by the invention has the effects of relieving itching, diminishing inflammation, inhibiting bacteria and killing bacteria, particularly has obvious effects on fungal infection and eczema infection, is safe and non-irritant to use, and is suitable for external administration of children.)

1. The children eczema ointment is characterized in that: is prepared from the following raw materials in part by weight

2-5 parts of hexadecanol, 1-6 parts of octadecanol, 1-2 parts of oleic acid, 2-5 parts of fatty acid monoglyceride, 1-2 parts of paraffin, 3-6 parts of glycerol, 1-2 parts of propylene glycol, 4-7 parts of borneol, 1-2 parts of miconazole nitrate, 0.1-0.3 part of azone, 0.1-0.3 part of dimethyl sulfoxide, 0.1-0.3 part of fatty alcohol polyoxyethylene ether, 0.1-0.3 part of tween-20, 0.1-0.3 part of methylparaben and 70-80 parts of water.

2. The ointment for treating children eczema as claimed in claim 1, wherein the ointment comprises 2 parts of cetyl alcohol, 1 part of stearyl alcohol, 1 part of oleic acid, 2 parts of fatty acid monoglyceride, 1 part of paraffin, 3 parts of glycerol, 1 part of propylene glycol, 4 parts of borneol, 1 part of miconazole nitrate, 0.1 part of azone, 0.1 part of dimethyl sulfoxide, 0.1 part of fatty alcohol-polyoxyethylene ether, 0.1 part of tween-20, 0.1 part of methylparaben and 70 parts of water.

3. The ointment for treating children eczema as claimed in claim 1, wherein the ointment comprises 5 parts of cetyl alcohol, 6 parts of stearyl alcohol, 2 parts of oleic acid, 5 parts of fatty acid monoglyceride, 2 parts of paraffin, 6 parts of glycerol, 2 parts of propylene glycol, 7 parts of borneol, 2 parts of miconazole nitrate, 0.3 part of azone, 0.3 part of dimethyl sulfoxide, 0.3 part of fatty alcohol-polyoxyethylene ether, 0.3 part of tween-20, 0.3 part of methylparaben and 80 parts of water.

4. The ointment for treating children eczema as claimed in claim 1, wherein the ointment comprises 3 parts of cetyl alcohol, 2 parts of stearyl alcohol, 1 part of oleic acid, 3 parts of fatty acid monoglyceride, 1 part of paraffin, 4 parts of glycerol, 1 part of propylene glycol, 5 parts of borneol, 1 part of miconazole nitrate, 0.2 part of azone, 0.1 part of dimethyl sulfoxide, 0.1 part of fatty alcohol-polyoxyethylene ether, 0.2 part of tween-20, 0.1 part of methylparaben and 75 parts of water.

5. The ointment for treating children eczema as claimed in claim 1, wherein the ointment comprises 4 parts of cetyl alcohol, 3 parts of stearyl alcohol, 2 parts of oleic acid, 4 parts of fatty acid monoglyceride, 2 parts of paraffin, 5 parts of glycerol, 2 parts of propylene glycol, 6 parts of borneol, 2 parts of miconazole nitrate, 0.3 part of azone, 0.2 part of dimethyl sulfoxide, 0.2 part of fatty alcohol-polyoxyethylene ether, 0.3 part of tween-20, 0.2 part of methylparaben and 76 parts of water.

6. The ointment for treating children eczema as claimed in claim 1, further comprising an auxiliary material, wherein the auxiliary material is prepared from the following raw materials in parts by weight

5-6 parts of borneol, 44-45 parts of talcum powder, 23-24 parts of zinc oxide and 26-27 parts of calcium carbonate.

7. The ointment for treating children eczema as claimed in claim 6, wherein the ointment comprises 5 parts of borneol, 44 parts of talcum powder, 23 parts of zinc oxide and 26 parts of calcium carbonate.

8. The ointment for treating children eczema as claimed in claim 6, wherein the ointment comprises 6 parts of borneol, 45 parts of talcum powder, 24 parts of zinc oxide and 27 parts of calcium carbonate.

9. A method for preparing an ointment for eczema of children as claimed in any one of claims 1 to 8, which comprises the steps of:

mixing and heating hexadecanol, octadecanol, propylene glycol, dimethyl sulfoxide and fatty alcohol-polyoxyethylene ether with water to obtain a water phase mixture;

Mixing oleic acid, fatty acid monoglyceride, glycerol, paraffin, azone, tween-20, and methyl hydroxybenzoate, and heating to obtain oil phase mixture;

grinding borneol and mixing the ground borneol and miconazole nitrate to obtain an additive, and heating to 30-40 ℃;

mixing and stirring the water phase mixture and the oil phase mixture, reducing the temperature to 30-40 ℃ in the stirring process, and continuously stirring for 5min to obtain a paste;

and pouring the additives into the paste, continuously stirring for 10-15 min, cooling, and subpackaging.

Technical Field

The invention belongs to the field of eczema medicaments, and particularly relates to a children eczema ointment and a preparation method thereof.

Background

Eczema is a superficial dermal and epidermal inflammation caused by various internal and external factors, and the cause of the disease is complex. The existing eczema treatment method is generally an external medicament and an internal medicament, but the intestines and stomach of children are weak and are not suitable for the internal medicament, and the existing external medicament has great irritation to the skin, so that the skin allergy and even the injury of the children are easily caused.

Disclosure of Invention

The invention provides an ointment for treating children eczema, and provides an external medicament suitable for treating children eczema.

The invention is realized by the following technical scheme.

The children eczema ointment is prepared from the following raw materials in parts by weight:

2-5 parts of hexadecanol, 1-6 parts of octadecanol, 1-2 parts of oleic acid, 2-5 parts of fatty acid monoglyceride, 1-2 parts of paraffin, 3-6 parts of glycerol, 1-2 parts of propylene glycol, 4-7 parts of borneol, 1-2 parts of miconazole nitrate, 0.1-0.3 part of azone, 0.1-0.3 part of dimethyl sulfoxide, 0.1-0.3 part of fatty alcohol polyoxyethylene ether, 0.1-0.3 part of tween-20, 0.1-0.3 part of methylparaben and 70-80 parts of water.

In a specific embodiment, 2 parts of cetyl alcohol, 1 part of stearyl alcohol, 1 part of oleic acid, 2 parts of fatty acid monoglyceride, 1 part of paraffin, 3 parts of glycerol, 1 part of propylene glycol, 4 parts of borneol, 1 part of miconazole nitrate, 0.1 part of azone, 0.1 part of dimethyl sulfoxide, 0.1 part of fatty alcohol-polyoxyethylene ether, 0.1 part of tween-20, 0.1 part of methylparaben and 70 parts of water.

In a specific embodiment, 5 parts of hexadecanol, 6 parts of octadecanol, 2 parts of oleic acid, 5 parts of fatty acid monoglyceride, 2 parts of paraffin, 6 parts of glycerol, 2 parts of propylene glycol, 7 parts of borneol, 2 parts of miconazole nitrate, 0.3 part of azone, 0.3 part of dimethyl sulfoxide, 0.3 part of fatty alcohol-polyoxyethylene ether, 0.3 part of tween-20, 0.3 part of methyl paraben and 80 parts of water.

In a specific embodiment, 3 parts of hexadecanol, 2 parts of octadecanol, 1 part of oleic acid, 3 parts of fatty acid monoglyceride, 1 part of paraffin, 4 parts of glycerol, 1 part of propylene glycol, 5 parts of borneol, 1 part of miconazole nitrate, 0.2 part of azone, 0.1 part of dimethyl sulfoxide, 0.1 part of fatty alcohol-polyoxyethylene ether, 0.2 part of tween-20, 0.1 part of methylparaben and 75 parts of water.

In a specific embodiment, 4 parts of hexadecanol, 3 parts of octadecanol, 2 parts of oleic acid, 4 parts of fatty acid monoglyceride, 2 parts of paraffin, 5 parts of glycerol, 2 parts of propylene glycol, 6 parts of borneol, 2 parts of miconazole nitrate, 0.3 part of azone, 0.2 part of dimethyl sulfoxide, 0.2 part of fatty alcohol-polyoxyethylene ether, 0.3 part of tween-20, 0.2 part of methylparaben and 76 parts of water.

In a specific embodiment, the ointment for treating children eczema further comprises an auxiliary material, wherein the auxiliary material is prepared from the following raw materials in parts by weight

5-6 parts of borneol, 44-45 parts of talcum powder, 23-24 parts of zinc oxide and 26-27 parts of calcium carbonate.

In a specific embodiment, the composition comprises 5 parts of borneol, 44 parts of talcum powder, 23 parts of zinc oxide and 26 parts of calcium carbonate.

In a specific embodiment, 6 parts of borneol, 45 parts of talcum powder, 24 parts of zinc oxide and 27 parts of calcium carbonate.

The application also provides a preparation method of the children eczema ointment, which comprises the following steps:

Mixing and heating hexadecanol, octadecanol, propylene glycol, dimethyl sulfoxide and fatty alcohol-polyoxyethylene ether with water to obtain a water phase mixture;

mixing oleic acid, fatty acid monoglyceride, glycerol, paraffin, azone, tween-20, and methyl hydroxybenzoate, and heating to obtain oil phase mixture;

grinding borneol and mixing the ground borneol and miconazole nitrate to obtain an additive, and heating to 30-40 ℃;

mixing and stirring the water phase mixture and the oil phase mixture, reducing the temperature to 30-40 ℃ in the stirring process, and continuously stirring for 5min to obtain a paste;

and pouring the additives into the paste, continuously stirring for 10-15 min, cooling, and subpackaging.

The invention has the beneficial effects that:

the miconazole nitrate can inhibit the synthesis of fungal cell membranes and kill fungi, all the medicinal components are matched with each other, so that the ointment for treating the eczema provided by the invention has the effects of relieving itching, diminishing inflammation, inhibiting bacteria and killing bacteria, particularly has obvious effects on fungal infection and eczema infection, is safe and non-irritant to use, and is suitable for external administration of children.

Detailed Description

The technical solution of the present invention is further described below, but the scope of the claimed invention is not limited to the described.

The invention provides an ointment for treating children eczema, which is prepared from the following raw materials in parts by weight:

2-5 parts of hexadecanol, 1-6 parts of octadecanol, 1-2 parts of oleic acid, 2-5 parts of fatty acid monoglyceride, 1-2 parts of paraffin, 3-6 parts of glycerol, 1-2 parts of propylene glycol, 4-7 parts of borneol, 1-2 parts of miconazole nitrate, 0.1-0.3 part of azone, 0.1-0.3 part of dimethyl sulfoxide, 0.1-0.3 part of fatty alcohol polyoxyethylene ether, 0.1-0.3 part of tween-20, 0.1-0.3 part of methylparaben and 70-80 parts of water.

The invention provides a preparation method of an ointment for treating children eczema, which comprises the following steps:

mixing and heating hexadecanol, octadecanol, propylene glycol, dimethyl sulfoxide and fatty alcohol-polyoxyethylene ether with water to obtain a water phase mixture;

mixing oleic acid, fatty acid monoglyceride, glycerol, paraffin, azone, tween-20, and methyl hydroxybenzoate, and heating to obtain oil phase mixture;

grinding borneol and mixing the ground borneol and miconazole nitrate to obtain an additive, and heating to 30-40 ℃;

mixing and stirring the water phase mixture and the oil phase mixture, reducing the temperature to 30-40 ℃ in the stirring process, and continuously stirring for 5min to obtain a paste;

and pouring the additives into the paste, continuously stirring for 10-15 min, cooling, and subpackaging.