包含至少一种局部唑抗真菌物质的用于局部使用的药物组合物

文档序号:1909075 发布日期:2021-11-30 浏览:17次 >En<

阅读说明:本技术 包含至少一种局部唑抗真菌物质的用于局部使用的药物组合物 (Pharmaceutical composition for topical use comprising at least one topical azole antifungal substance ) 是由 C·布考特 A·丹尼斯 塞维琳·西古拉尼 于 2020-04-01 设计创作,主要内容包括:披露了一种用于局部使用的药物组合物,其呈油包水乳液的形式,对于100%的其重量,包含:-按重量计从0.3%至5%的至少一种局部唑抗真菌物质;-按重量计从60%至90%的胶凝水相(Al);-按重量计从9.7%至35%的脂肪相(A2),该脂肪相包含至少一种油和乳化体系,该乳化体系包含至少一种乳化表面活性剂(S1)和至少一种乳化表面活性剂(S2)的组合,该乳化表面活性剂(S1)选自由烷基多糖苷组合物以及烷基多糖苷和脂肪醇组合物组成的组的元素,该乳化表面活性剂(S2)选自由聚甘油酯、烷氧基化聚甘油酯、聚二醇聚羟基硬脂酸酯、聚甘油聚羟基硬脂酸酯、以及烷氧基化聚甘油聚羟基硬脂酸酯组成的组的元素。(A pharmaceutical composition for topical use is disclosed, in the form of a water-in-oil emulsion comprising, for 100% of its weight: -from 0.3 to 5% by weight of at least one topical azole antifungal substance; -from 60 to 90% by weight of a gelled aqueous phase (Al); -from 9.7 to 35% by weight of a fatty phase (a2) comprising at least one oil and an emulsifying system comprising a combination of at least one emulsifying surfactant (S1) and at least one emulsifying surfactant (S2), the emulsifying surfactant (S1) being selected from elements of the group consisting of alkyl polyglycoside compositions and alkyl polyglycoside and fatty alcohol compositions, the emulsifying surfactant (S2) being selected from elements of the group consisting of polyglycerol esters, alkoxylated polyglycerol esters, polyglycol polyhydroxystearate, polyglycerol polyhydroxystearate, and alkoxylated polyglycerol polyhydroxystearate.)

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