阅读说明：本技术 复方酮康唑发用洗剂及其制备方法 (Compound ketoconazole lotion for hair and preparation method thereof ) 是由 庄永辉 于 2019-08-21 设计创作，主要内容包括：本发明提供了一种复方酮康唑发用洗剂及其制备方法。本发明的复方酮康唑发用洗剂包括如下组分：酮康唑、增稠剂、丙酸氯倍他索、乙醇、乳化剂、抗氧化剂、酸度调节剂、胭脂红、纯化水。本发明的制备方法：取脂肪酰二乙醇胺加入配料锅A中加热,加入酮康唑搅拌得酮康唑溶液；在乙醇中加入丙酸氯倍他索,得丙酸氯倍他索溶液；在配料锅B中加入纯化水、十二烷基硫酸钠、亚硫酸氢钠、柠檬酸、胭脂红、丙酸氯倍他索溶液,搅拌,再加入酮康唑溶液；用纯化水置换配料锅A,泵入配料锅B,配料锅B搅拌,取样送检合格后灌装。本发明的复方酮康唑发用洗剂能有效预防、治疗多种真菌引起的感染。且具有良好的发泡性能,头干后梳理性好,发质柔顺。(The invention provides a compound ketoconazole lotion for hair and a preparation method thereof. The compound ketoconazole lotion for hair comprises the following components: ketoconazole, a thickening agent, clobetasol propionate, ethanol, an emulsifier, an antioxidant, an acidity regulator, carmine and purified water. The preparation method comprises the following steps: adding fatty acyl diethanolamine into a mixing pot A, heating, adding ketoconazole, and stirring to obtain a ketoconazole solution; adding clobetasol propionate into ethanol to obtain a clobetasol propionate solution; adding purified water, sodium dodecyl sulfate, sodium bisulfite, citric acid, carmine and clobetasol propionate solution into a batching pot B, stirring, and adding ketoconazole solution; replacing the mixing pot A with purified water, pumping into the mixing pot B, stirring in the mixing pot B, sampling, inspecting and filling after being qualified. The compound ketoconazole lotion for hair can effectively prevent and treat infection caused by various fungi. And has good foaming performance, good combing performance after drying the hair and smooth hair quality.)

1. the compound ketoconazole lotion for hair is characterized in that: the paint comprises the following components in percentage by weight:

1-2% of ketoconazole;

8-15% of a thickening agent;

0.01 to 0.05 percent of clobetasol propionate;

8-15 parts of ethanol;

6-10% of emulsifier;

0.5 to 3 percent of antioxidant;

0.2 to 0.5 percent of acidity regulator;

0.02-0.05% of carmine;

And (4) purifying the balance of water.

2. The compound ketoconazole hair lotion as claimed in claim 1, which is characterized in that: the thickener is fatty acyl diethanolamine.

3. The compound ketoconazole hair lotion as claimed in claim 1, which is characterized in that: the emulsifier is sodium dodecyl sulfate.

4. the compound ketoconazole hair lotion as claimed in claim 1, which is characterized in that: the antioxidant is sodium bisulfite.

5. the compound ketoconazole hair lotion as claimed in claim 1, which is characterized in that: the acidity regulator is citric acid.

6. The preparation method of the compound ketoconazole hair lotion as claimed in claims 1-5, which comprises the following steps:

(1) adding fatty acyl diethanolamine into a mixing pot A, heating to 60-65 ℃, adding ketoconazole, and stirring for 30 minutes to obtain a ketoconazole solution;

(2) Adding clobetasol propionate into ethanol, and dissolving to obtain clobetasol propionate solution;

(3) Adding purified water into the mixing pot B, adding sodium dodecyl sulfate, sodium bisulfite, citric acid, carmine and clobetasol propionate solution, mixing, stirring for 30 minutes, and adding ketoconazole solution;

(4) Replacing the mixing pot A2 times with purified water, each time for 2-5 minutes, pumping into the mixing pot B, stirring for 45 minutes, sampling, inspecting, and packaging.

Technical Field

The invention relates to the technical field of medicinal lotion, in particular to compound ketoconazole hair lotion and a preparation method thereof.

background

The compound ketoconazole lotion for hair is mainly used for treating and preventing infection caused by various fungi, such as pityriasis capitis, seborrheic dermatitis and tinea versicolor. The active ingredient ketoconazole can inhibit the biosynthesis of ergosterol on fungal cell membranes, influence the permeability of the cell membranes and inhibit the growth of the cell membranes. Can be used for treating superficial and deep fungal infection of head. The effective component clobetasol propionate is an artificially synthesized high-efficiency topical glucocorticoid medicine, and has good anti-inflammatory effect on skin. The common drug effects of the ketoconazole and the clobetasol propionate respectively play an additive or enhanced synergistic effect in the compound, and the drug effects of the two different main components play a complementary effect in the compound, thereby having good anti-inflammatory and antipruritic effects.

The existing compound ketoconazole lotion for hair on the market generally has the problems of poor foaming performance, insufficient smoothness of hair after hair drying and the like.

Disclosure of Invention

In order to solve the defects, the invention aims to provide the compound ketoconazole hair lotion which can fully exert the bacteriostatic action of ketoconazole and clobetasol propionate, has good foaming performance, good combing property after the hair is dried and smooth hair quality.

The invention is realized by the following technical scheme: the compound ketoconazole lotion for hair comprises the following components in percentage by weight:

1-2% of ketoconazole;

8-15% of a thickening agent;

0.01 to 0.05 percent of clobetasol propionate;

8-15 parts of ethanol;

6-10% of emulsifier;

0.5 to 3 percent of antioxidant;

0.2 to 0.5 percent of acidity regulator;

0.02-0.05% of carmine;

And (4) purifying the balance of water.

further, the thickener is fatty acyl diethanolamine.

Further, the emulsifier is sodium lauryl sulfate.

Further, the antioxidant is sodium bisulfite.

Further, the acidity regulator is citric acid.

The invention also aims to provide a preparation method of the compound ketoconazole hair lotion, which comprises the following steps:

(1) Adding fatty acyl diethanolamine into a mixing pot A, heating to 60-65 ℃, adding ketoconazole, and stirring for 30 minutes to obtain a ketoconazole solution;

(2) adding clobetasol propionate into ethanol, and dissolving to obtain clobetasol propionate solution;

(3) adding purified water into the mixing pot B, adding sodium dodecyl sulfate, sodium bisulfite, citric acid, carmine and clobetasol propionate solution, mixing, stirring for 30 minutes, and adding ketoconazole solution;

(4) replacing the mixing pot A2 times with purified water, each time for 2-5 minutes, pumping into the mixing pot B, stirring for 45 minutes, sampling, inspecting, and packaging.

The invention has the beneficial effects that: the invention relates to a compound ketoconazole lotion for hair, which mainly comprises ketoconazole and clobetasol propionate as active ingredients and can effectively prevent and treat infection caused by various fungi. Wherein, the active ingredient ketoconazole can inhibit the biosynthesis of ergosterol of fungal cell membranes, influence the permeability of the cell membranes and inhibit the growth of the cell membranes, and can be used for treating superficial and deep fungal infections of the head. The effective component clobetasol propionate is an artificially synthesized high-efficiency topical glucocorticoid medicine, and has good anti-inflammatory effect on skin. The common drug effects of the ketoconazole and the clobetasol propionate respectively play an additive or enhanced synergistic effect in the compound, and the drug effects of the two different main components play a complementary effect in the compound, thereby having good anti-inflammatory and antipruritic effects. Meanwhile, a proper amount of thickening agent, emulsifying agent, antioxidant and acidity regulator are added into the compound ketoconazole hair lotion. The thickening agent makes the property and performance of the compound ketoconazole hair lotion more stable while the bacteriostatic action of the ketoconazole and the clobetasol propionate is fully exerted. The antioxidant can enhance the natural resistance of scalp, resist oxidation and inflammation, and effectively protect scalp health. The emulsifier has the function of conditioning hair, and can isolate external injury and make hair more pliable. The acidity regulator neutralizes pH of the hair lotion, and is mild, safe and non-irritant.

Detailed Description

Table 1: example one-three components of a compound ketoconazole lotion for hair use.

composition/Kg	Example one	Example two	EXAMPLE III
				ketoconazole	1.5	1	2
Fatty acyl diethanol amines	11.5	8	15
				Clobetasol propionate	0.03	0.01	0.05
Ethanol	11.5	8	15
				sodium dodecyl sulfate	8	6	10
Sodium bisulfite	1.75	0.5	3
				citric acid	0.35	0.2	0.5
carmine	0.04	0.02	0.05
				purified water	65.33	76.27	54.4

According to the component compositions of the examples in table 1, the compound ketoconazole lotion for hair is prepared according to the following method:

(1) Adding fatty acyl diethanolamine into a mixing pot A, heating to 65 ℃, adding ketoconazole, and stirring for 30 minutes to obtain a ketoconazole solution;

(2) Adding clobetasol propionate into ethanol, and dissolving to obtain clobetasol propionate solution;

(3) Adding 1/3 purified water into the mixing pot B, adding sodium dodecyl sulfate, sodium bisulfite, citric acid, carmine and clobetasol propionate solution, mixing, stirring for 30 min, and adding ketoconazole solution;

(4) Replacing the batching pot A2 times with purified water of 1/3 respectively, wherein the replacement time is 5 minutes each time, pumping the batching pot B, stirring the batching pot B for 45 minutes, sampling, inspecting and filling after being qualified.