阅读说明：本技术 用于治疗与骨丢失或降低的肌肉功能有关的病理状况的微小rna 19a/19b (MicroRNA 19A/19B for the treatment of pathological conditions associated with bone loss or reduced muscle function ) 是由 E.黑泽 H.泰帕莱恩梅基 H.赛托 于 2018-04-06 设计创作，主要内容包括：本发明涉及微小RNAs 19a和19b的抑制剂及其用于治疗或预防与骨丢失有关的状况或疾病、特别是骨质疏松症和成骨不全(OI)的用途。所述抑制剂单独或当与甲状旁腺激素或其重组片段组合施用时,也可用于诱导骨中的合成作用。本发明进一步涉及微小RNAs 19a和19b的抑制剂及其用于治疗或预防与降低的肌肉功能有关的状况或疾病、特别是肌肉变性和肌肉萎缩的用途。所述抑制剂也可用于稳定和/或增强肌肉功能。此外,微小RNAs 19a和19b的抑制剂可用于治疗或预防癌症相关的骨破坏或骨转移。(The present invention relates to inhibitors of micro RNAs 19a and 19b and their use for the treatment or prevention of conditions or diseases associated with bone loss, in particular osteoporosis and Osteogenesis Imperfecta (OI). The inhibitors may also be used to induce synthesis in bone, alone or when administered in combination with parathyroid hormone or recombinant fragments thereof. The invention further relates to inhibitors of micro RNAs 19a and 19b and their use for the treatment or prevention of conditions or diseases associated with reduced muscle function, in particular muscle degeneration and muscle atrophy. The inhibitors may also be used to stabilize and/or enhance muscle function. In addition, inhibitors of micrornas 19a and 19b may be useful in the treatment or prevention of cancer-associated bone destruction or bone metastasis.)