阅读说明：本技术 一种治疗前列腺炎和前列腺增生的药物配方及其制备工艺 (A Chinese medicinal composition for treating prostatitis and prostatic hyperplasia, and its preparation method ) 是由 查国章 刘立鹏 李江 王琼林 查宇 于 2021-09-10 设计创作，主要内容包括：本发明公开了一种治疗前列腺炎和前列腺增生的药物配方及其制备工艺,包括以下重量组分,头孢哌酮钠舒巴坦钠1000～8000mg,依地酸二钠2～40mg,地塞米松1～20mg,左布比卡因20～200mg,普鲁卡因40～400mg。本配伍组方通过前列腺微针注射直接给药,从而最大限度地在前列腺体内发挥抗菌消炎、减轻前列腺纤维化的作用,适用于治疗各种慢性前列腺炎和良性前列腺增生。通过大量临床病例证明,本配方具有疗效显著、治疗无痛苦、安全无副作用等优点。(The invention discloses a pharmaceutical formula for treating prostatitis and prostatic hyperplasia and a preparation process thereof, wherein the pharmaceutical formula comprises the following components, by weight, 1000-8000 mg of cefoperazone sodium and sulbactam sodium, 2-40 mg of edetate disodium, 1-20 mg of dexamethasone, 20-200 mg of levobupivacaine and 40-400 mg of procaine. The compatible prescription is directly administrated by injecting prostate micro-needle, thereby exerting the functions of antibiosis, anti-inflammation and prostate fibrosis reduction in prostate to the maximum extent, and being suitable for treating various chronic prostatitis and benign prostatic hyperplasia. A large number of clinical cases prove that the formula has the advantages of obvious curative effect, no pain in treatment, safety, no side effect and the like.)

1. A pharmaceutical formulation for treating prostatitis and prostatic hyperplasia is characterized by comprising the following components, by weight, 1000-8000 mg of cefoperazone sodium and sulbactam sodium, 2-40 mg of edetate disodium, 1-20 mg of dexamethasone, 20-200 mg of levobupivacaine, and 40-400 mg of procaine.

2. The pharmaceutical formulation for treating prostatitis and prostatic hyperplasia according to claim 1, which comprises 1000mg of cefoperazone sodium and sulbactam sodium, 40mg of edetate disodium, 20mg of dexamethasone, 20mg of levobupivacaine and 40-400 mg of procaine.

3. The pharmaceutical formulation for treating prostatitis and prostatic hyperplasia according to claim 1, which comprises 2000mg of cefoperazone sodium sulbactam sodium, 5mg of edetate disodium, 15mg of dexamethasone, 100mg of levobupivacaine and 200mg of procaine by weight.

4. The pharmaceutical formulation for treating prostatitis and prostatic hyperplasia according to claim 1, which comprises 8000mg of cefoperazone sodium sulbactam sodium, 40mg of edetate disodium, 20mg of dexamethasone, 200mg of levobupivacaine, and 400mg of procaine.

5. The pharmaceutical formulation for treating prostatitis and prostatic hyperplasia and preparation process thereof as claimed in claim 1, wherein the preparation method comprises:

(1) dissolving cefoperazone sodium and sulbactam sodium in a proper amount of 0.9% sodium chloride solution for injection, and then diluting the dissolved cefoperazone sodium and sulbactam sodium to 5-50 ml by using the same solution, wherein the molar concentration of the dissolved cefoperazone sodium is 0.2mol/L, and the molar concentration of the dissolved sulbactam sodium is 0.31mol/L

(2) Then diluting the solution to 5-50 ml by using the same solution, wherein the molar concentration of the dissolved cefoperazone sodium is 0.2mol/L, and the molar concentration of the dissolved sulbactam sodium is 0.31 mol/L.

Technical Field

The invention relates to the field of medicines, in particular to a medicine formula for treating prostatitis and prostatic hyperplasia and a preparation process thereof.

Background

Chronic prostatitis is a common male disease with high incidence rate, intractable and long course of disease, is often accompanied by prostatic hyperplasia and prostatic calculus, and can cause secondary male infertility and sexual dysfunction, thereby bringing great pain to patients. Clinical urology surgery and male special departments at home and abroad have a plurality of treatment methods for diseases such as prostatitis, but the diseases are usually not cured for a long time and are repeatedly attacked. Therefore, the prior art treatment has not met the need for such a treatment.

For the above reasons, a pharmaceutical formulation for treating prostatitis and prostatic hyperplasia is a technical problem to be solved by those skilled in the art.

Disclosure of Invention

The invention designs a medicine formula for treating prostatitis and prostatic hyperplasia, which comprises the following components, by weight, 1000-8000 mg of cefoperazone sodium and sulbactam sodium, 2-40 mg of edetate disodium, 1-20 mg of dexamethasone, 20-200 mg of levobupivacaine and 40-400 mg of procaine.

Further comprises the following components by weight, 1000mg of cefoperazone sodium and sulbactam sodium, 40mg of edetate disodium, 20mg of dexamethasone, 20mg of levobupivacaine and 40-400 mg of procaine.

Further comprises the following components by weight, 2000mg of cefoperazone sodium and sulbactam sodium, 5mg of edetate disodium, 15mg of dexamethasone, 100mg of levobupivacaine and 200mg of procaine.

Further comprises 8000mg of cefoperazone sodium and sulbactam sodium, 40mg of edetate disodium, 20mg of dexamethasone, 200mg of levobupivacaine and 400mg of procaine.

Further, the preparation method comprises the following steps:

(1) dissolving cefoperazone sodium and sulbactam sodium in a proper amount of 0.9% sodium chloride solution for injection, and then diluting the dissolved cefoperazone sodium and sulbactam sodium to 5-50 ml by using the same solution, wherein the molar concentration of the dissolved cefoperazone sodium is 0.2mol/L, and the molar concentration of the dissolved sulbactam sodium is 0.31mol/L

(2) Then diluting the solution to 5-50 ml by using the same solution, wherein the molar concentration of the dissolved cefoperazone sodium is 0.2mol/L, and the molar concentration of the dissolved sulbactam sodium is 0.31mol/L

By adopting the technical scheme, the method has the following technical effects:

1. the medicine is safe and has no toxic or side effect, and scientific medicine selection and strict scientific prescription are adopted, so that the medicine is effective and the safety of the medicine is ensured.

2. The effect is obvious, the obvious effect can be seen generally for 3 times, the perineum dropping and swelling symptom and the lower urinary tract symptom can be relieved after the injection, the urination is obvious and smooth, the sexual function of most patients is improved or recovered to be normal, and the effect is more obvious when the symptom is more serious.

3. The medicine has high cure rate and no recurrence, and the local application of the medicine greatly improves the high concentration of the medicine, effectively kills germs, is not easy to generate drug resistance and recovers most physiological functions of prostate.

4. Short treatment course, improved safety of the medicine, improved administration route, and shortened treatment period.

Detailed Description

The present invention will be further explained below in order to make the technical means, inventive features, objectives and effects of the present invention easy to understand.

A pharmaceutical formula for treating prostatitis and prostatic hyperplasia comprises the following components, by weight, 1000-8000 mg of cefoperazone sodium and sulbactam sodium, 2-40 mg of edetate disodium, 1-20 mg of dexamethasone, 20-200 mg of levobupivacaine, and 40-400 mg of procaine.

The invention further discloses a pharmaceutical composition which comprises the following components, by weight, 1000mg of cefoperazone sodium and sulbactam sodium, 40mg of edetate disodium, 20mg of dexamethasone, 20mg of levobupivacaine and 40-400 mg of procaine.

As further illustration of the invention, the composition comprises the following components, by weight, 2000mg of cefoperazone sodium and sulbactam sodium, 5mg of edetate disodium, 15mg of dexamethasone, 100mg of levobupivacaine and 200mg of procaine.

The invention further discloses a pharmaceutical composition which comprises 8000mg of cefoperazone sodium and sulbactam sodium, 40mg of edetate disodium, 20mg of dexamethasone, 200mg of levobupivacaine and 400mg of procaine.

Example (b):

a pharmaceutical formula for treating prostatitis and prostatic hyperplasia comprises the following components, by weight, 1000-8000 mg of cefoperazone sodium and sulbactam sodium, 2-40 mg of edetate disodium, 1-20 mg of dexamethasone, 20-200 mg of levobupivacaine, and 40-400 mg of procaine.

The preparation method comprises the following steps:

(1) dissolving cefoperazone sodium and sulbactam sodium in a proper amount of 0.9% sodium chloride solution for injection, and then diluting the dissolved cefoperazone sodium and sulbactam sodium to 5-50 ml by using the same solution, wherein the molar concentration of the dissolved cefoperazone sodium is 0.2mol/L, and the molar concentration of the dissolved sulbactam sodium is 0.31mol/L

(2) Then diluting the solution to 5-50 ml by using the same solution, wherein the molar concentration of the dissolved cefoperazone sodium is 0.2mol/L, and the molar concentration of the dissolved sulbactam sodium is 0.31mol/L

The using method comprises the following steps:

the injection administration technology of avoiding nerve vessels and inserting needles through the pelvic gaps of the perineum is adopted, so that the medicine can fully permeate to the infected focuses around the posterior urethra, the prostate, the seminal vesicle gland, the vas deferens, the epididymis and the like, and the medicine can diminish inflammation and sterilize and dredge the blocked prostate gland duct after entering.

The implementation case is as follows:

compared with the conventional oral, intramuscular injection or intravenous drip medicine treatment method, the method has the following advantages:

1. the medicine directly acts on the infected part, and the duration of the medicine effect is long;

2. the treatment process is easy, no operation is needed, the tissue is not damaged, the patient has no obvious pain, and the patient can move freely after receiving the treatment.

3. Avoid various adverse reactions such as serious dysbacteriosis in the body of a patient caused by long-term oral administration, intramuscular injection or intravenous drip of antibacterial drugs.

The application is as follows:

the medicine is administered by directional injection, the efficacy of the medicine can reach the focus part quickly, the effective absorption of the gland to the medicine can be promoted, the pathogen can be killed, the gland duct can be dredged, the histiocyte can be repaired, the cell metabolism can be promoted, and the relapse can be effectively prevented.

Case one: chua, male, age 21. Urine is ineffective, white drops are produced after urine, the whole night erects for more than 2 years, and the glans penis is scorched after the defecation and the lower abdomen distending pain after the urination are accompanied. And (3) diagnosis: the prostate is frequently suffered from small stones and chronic prostatitis. The comprehensive treatment measures mainly including directional injection administration are to start the administration through perineum injection. The treatment is carried out once a day, 10 times in total, and the patient goes to a hospital for a second treatment course after one month. The calculus is completely disappeared, and the image of the mild prostatitis is shown.

Case two: li Jie, male, 82 years old, frequent and frequent nocturia with urgency for 30 years, then aggravated for 3 days. Examining the body and wrapping the stem, the external hemorrhoids are visible. Anal examination: moderate enlargement of the prostate, tough and tough texture, shallow central sulcus, tenderness. And (3) diagnosis: the traditional Chinese medicine composition is used for treating prostatic hyperplasia and comprehensive treatment mainly based on directional injection after hospitalization, the symptoms of frequent micturition, urgent micturition are improved and the nocturia is reduced after three injections, the symptoms of frequent micturition, urgent micturition and dysuria disappear after one treatment course, and the nocturia is only 1-2 times per night and appears obvious morning brik.

Case three: zhangqi, male age 44, distending pain in perineum, aggravated by 2 years of sitting with pain in urethra and testis for 1 year. Checking: the urethral orifice is marked with flush and the left epididymis is marked with tenderness. Digital rectal examination: prostate slightly bigger, hard texture, obvious tenderness. And (3) diagnosis: prostatitis type iii (CPPS); adopts a personalized treatment scheme mainly based on directional injection administration. The urine begins to discharge waste residues after twice treatments once a day. On day four, urethral perfusion treatment (non-intubated method) was added once daily for a total of five times. After nine days of treatment, all symptoms completely disappeared before the visit.

Case four: a trip is a male 50 years old. Pain in the lower abdomen and perineum, burning sensation in the urethra during urination, and pain in the glans penis for 2 years. And (3) diagnosis: mud stones of the prostate; chronic prostatitis. By the comprehensive therapy mainly based on directional injection administration, a large amount of turbid substances are discharged from urine on the third day, and the symptoms of the sufferers are gradually improved after 8 times of treatment. After being continuously used for one month, the symptoms are completely absent, the urination is smooth and forceful, the patient does not get up to bed and urinate any more, and the patient can recover to be normal in the morning.

Case five: scholar, male 71 years old. Frequent micturition, urgent micturition, incomplete micturition, and frequent nocturia for a month. Has no obvious pain in urination and hematuria under the eyes. Diagnosis of prostatic hyperplasia (BPH), Chronic Bacterial Prostatitis (CBP), and multiple cyst of prostate. After the patient is admitted, a comprehensive treatment strategy mainly based on directional injection administration is adopted, the nocturia of the patient is obviously reduced by about 3-4 times per night after the first needle and the second needle compared with that before treatment, and a large amount of sediments are discharged in urine. After eleven treatments, the frequent, urgent and incomplete urination completely disappeared, and the patient was recovered and discharged.

Case six: tang Dynasty, male. Waiting for urine, branching urine for 8 years, and dripping white urine at the urethral orifice for 3 years, and diagnosing: chronic bacterial prostatitis (type II), chronic posterior urethritis. The comprehensive therapy mainly comprising directional injection administration is selected, after one treatment course (10 times), the phenomena of urethral orifice dripping and bifurcation of a patient are obviously relieved, but occasionally urine waits and urine is not exhausted, and after the second treatment course, the symptoms are completely disappeared and the whole body health condition is good.

Case seven: forest, male 39 years old, english. Fever, perineum distending pain, frequent micturition, urgent micturition and general debilitation without obvious inducement appear for more than 20 years, and the symptoms gradually get worse for 3 years. And (3) diagnosis: prostatitis, prostate, many tiny calcific foci; by adopting a comprehensive therapy mainly based on directional injection administration, after 14 times of treatment in the first treatment course, the self-induced dripping urine condition is obviously controlled, other symptoms are improved, after 12 days of treatment in the second treatment course, the dripping urine condition disappears, and the symptoms disappear before hospitalization.

Having thus described the basic principles and principal features of the invention, it will be appreciated by those skilled in the art that the invention is not limited by the embodiments described above, which are given by way of illustration only, but that various changes and modifications may be made therein without departing from the spirit and scope of the invention as defined by the appended claims and their equivalents.