阅读说明：本技术 2,6-二氨基吡啶化合物 (2, 6-diaminopyridine compound ) 是由 T·B·德拉姆 于 2019-08-29 设计创作，主要内容包括：本发明提供式I的化合物或其药学上可接受的盐,以及式I化合物用于治疗代谢病症,如2型糖尿病、心力衰竭、糖尿病性肾病和非酒精性脂肪性肝炎的用途：式I。(The present invention provides compounds of formula I, or pharmaceutically acceptable salts thereof, and the use of compounds of formula I for the treatment of metabolic disorders, such as type 2 diabetes, heart failure, diabetic nephropathy and non-alcoholic steatohepatitis:)

1. A compound of the formula:

wherein n is 1 or 2.

2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein n is 1.

3. The compound of claim 2, or a pharmaceutically acceptable salt thereof, wherein the compound is:

。

4. the compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein n is 2.

5. The compound of claim 4, or a pharmaceutically acceptable salt thereof, wherein the compound is:

。

6. the compound of claim 5, or a pharmaceutically acceptable salt thereof, wherein the compound is:

。

7. a method of treating type 2 diabetes in a patient, comprising administering to a patient in need of such treatment an effective amount of a compound of any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof.

8. A method of treating heart failure in a patient comprising administering to a patient in need of such treatment an effective amount of a compound of any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof.

9. A method of treating diabetic nephropathy in a patient, comprising administering to a patient in need of such treatment an effective amount of a compound of any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof.

10. A method of treating non-alcoholic steatohepatitis in a patient, comprising administering to a patient in need of such treatment an effective amount of a compound of any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof.

11. A compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, for use in therapy.

12. A compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, for use in the treatment of type 2 diabetes.

13. A compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, for use in the treatment of heart failure.

14. A compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, for use in the treatment of diabetic nephropathy.

15. A compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, for use in the treatment of non-alcoholic steatohepatitis.

16. A pharmaceutical composition comprising a compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers, diluents, or excipients.

17. A process for preparing a pharmaceutical composition comprising mixing a compound according to any one of claims 1 to 6, or a pharmaceutically acceptable salt thereof, with one or more pharmaceutically acceptable carriers, diluents or excipients.