阅读说明：本技术 一种含有盐酸阿比多尔的复方药物组合物及其用途 (Compound pharmaceutical composition containing arbidol hydrochloride and application thereof ) 是由 武卫 王淑啸 吴晓明 树立华 邓银来 沈玲 于 2020-06-24 设计创作，主要内容包括：本发明涉及医药组合物技术领域,具体提供了一种含有盐酸阿比多尔的复方药物组合物及其用途,该复方药物组合物包括3’,4’,5’,5,7-五甲氧基黄酮和盐酸阿比多尔,将盐酸阿比多尔和3’,4’,5’,5,7-五甲氧基黄酮联合给药,尤其是当两者的摩尔为3-9:10-50时,具有良好的抗病毒的协同作用,可作为抗病毒,尤其是抗乙型肝炎病毒的潜在药物。(The invention relates to the technical field of pharmaceutical compositions, and particularly provides a compound pharmaceutical composition containing arbidol hydrochloride and application thereof, wherein the compound pharmaceutical composition comprises 3',4',5',5, 7-pentamethoxyl flavone and arbidol hydrochloride, and the arbidol hydrochloride and the 3',4',5',5, 7-pentamethoxyl flavone are jointly administered, particularly when the molar ratio of the arbidol hydrochloride to the 3',4',5',5, 7-pentamethoxyl flavone is 3-9:10-50, the compound pharmaceutical composition has a good antiviral synergistic effect, and can be used as a potential medicament for resisting viruses, particularly hepatitis B viruses.)

1. A compound pharmaceutical composition containing arbidol hydrochloride is characterized by comprising 3',4',5',5, 7-pentamethoxyl flavone and arbidol hydrochloride.

2. The compound pharmaceutical composition containing arbidol hydrochloride according to claim 1, wherein the mass ratio of the 3',4',5',5, 7-pentamethoxyflavone to the arbidol hydrochloride is 3-9: 10-50.

3. The compound pharmaceutical composition containing arbidol hydrochloride according to claim 1 or 2, wherein the mass ratio of the 3',4',5',5, 7-pentamethoxyflavone to the arbidol hydrochloride is 3:10, 3:50, 9:30 or 9: 50.

4. The compound pharmaceutical composition containing arbidol hydrochloride according to claim 3, wherein the mass ratio of the 3',4',5',5, 7-pentamethoxyl flavone to the arbidol hydrochloride is 9: 30.

5. The compound pharmaceutical composition containing arbidol hydrochloride according to any of claims 1-4, further comprising optionally one or more pharmaceutically acceptable carriers; the pharmaceutically acceptable carrier is selected from at least one of pharmaceutically acceptable solvents, solubilizers, cosolvents, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, osmotic pressure regulators, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adherents, integration agents, permeation enhancers, pH regulators, buffers, plasticizers, surfactants, thickeners, encapsulation agents, humectants, absorbents, diluents, flocculants and deflocculants, filter aids, release retardants, polymeric matrix materials, and film-forming materials.

6. Use of the compound pharmaceutical composition containing arbidol hydrochloride according to any one of claims 1 to 5 in the preparation of a medicament for preventing or treating viral infection.

7. The use according to claim 6, wherein the viral infection is a hepatitis virus infection; the hepatitis virus infection is hepatitis B virus infection.

8. Use according to claim 6 or 7, further comprising optionally one or more pharmaceutically acceptable carriers.

9. The use according to claim 8, wherein the pharmaceutically acceptable carrier is selected from at least one of pharmaceutically acceptable solvents, solubilizers, co-solvents, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, tonicity adjusting agents, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adherents, integration agents, permeation enhancers, pH adjusting agents, buffers, plasticizers, surfactants, thickeners, encapsulation agents, humectants, absorbents, diluents, flocculants and deflocculants, filter aids, release retardants, polymeric matrix materials, and film-forming materials.

10. Use according to any one of claims 6 to 9, characterized in that the medicament is a gel, cream, tablet, capsule, powder, mixture, pill, granule, solution, syrup, electuary, suppository, aerosol, patch, ointment, injection, spray, liniment, tincture, cataplasm, paste or lotion.

Technical Field

The invention relates to the technical field of pharmaceutical compositions, in particular to a compound pharmaceutical composition containing arbidol hydrochloride and application thereof.

Background

Hepatitis b is a serious disease harmful to human health worldwide caused by Hepatitis B Virus (HBV), persistent infection of HBV can cause liver cirrhosis, liver cancer, liver failure and other liver diseases, the mortality rate is high, WHO has listed hepatitis b as the ninth cause of death worldwide, although hepatitis b vaccines are widely used and have effective prevention on hepatitis b in a certain range, the WHO has the problem of no response and adverse reaction, and how to treat existing patients is also an urgent problem to be solved in future research and development.

Arbidol Hydrochloride (AH), the chemical name of 6-bromo-4- (dimethylaminomethyl) -5-hydroxy-1-methyl-2- (phenylthiomethyl) -1H-indole-3-carboxylic acid ethyl ester Hydrochloride monohydrate, is an interferon inducer, an immunopotentiator and an anti-influenza virus medicament, and has become a research hotspot of an antiviral medicament due to low toxicity and good antiviral effect. In addition, some flavonoids extracted from natural drugs are considered to have antiviral effects, but most of them are still in experimental research stage.

Therefore, the search for new antiviral drugs is of great importance for the prevention or treatment of hepatitis b.

Disclosure of Invention

Therefore, the invention aims to provide a compound pharmaceutical composition containing the arbidol hydrochloride and application thereof, wherein the compound pharmaceutical composition comprises 3',4',5',5, 7-pentamethoxyl flavone and the arbidol hydrochloride.

Preferably, the mass ratio of the 3',4',5',5, 7-pentamethoxyl flavone to the arbidol hydrochloride is 3-9: 10-50.

Further, the mass ratio of the 3',4',5',5, 7-pentamethoxyl flavone to the arbidol hydrochloride is 3:10, 9:30 or 9: 50.

Further, the mass ratio of the 3',4',5',5, 7-pentamethoxyl flavone to the arbidol hydrochloride is 9: 30.

The invention also provides application of any compound pharmaceutical composition containing the arbidol hydrochloride in preparing a medicament for preventing or treating virus infection.

Further, the viral infection is hepatitis virus infection.

Further, the hepatitis virus infection is hepatitis b virus infection.

Further, one or more pharmaceutically acceptable carriers are optionally included.

Further, the pharmaceutically acceptable carrier is selected from at least one of pharmaceutically acceptable solvents, solubilizers, solubilizing agents, emulsifiers, colorants, binders, disintegrants, fillers, lubricants, wetting agents, tonicity adjusting agents, stabilizers, glidants, flavoring agents, preservatives, suspending agents, coating materials, fragrances, anti-adherents, integration agents, penetration enhancers, pH adjusting agents, buffers, plasticizers, surfactants, thickeners, encapsulation agents, humectants, absorbents, diluents, flocculants and deflocculants, filter aids, release retardants, polymeric matrix materials, and film-forming materials.

Further, the medicine is gel, cream, tablet, capsule, powder, mixture, pill, granule, solution, syrup, soft extract, suppository, aerosol, emplastrum, ointment, injection, spray, liniment, tincture, wet application, paste or lotion.

The technical scheme of the invention has the following advantages:

the inventor finds that in the research on the compatibility pharmacological activity of the flavonoid compound and the arbidol hydrochloride, the arbidol hydrochloride and 3',4',5',5, 7-pentamethoxyl flavone (hereinafter referred to as pentamethoxyl flavone) are jointly administered, especially when the molar ratio of the arbidol hydrochloride and the pentamethoxyl flavone is 3-9: 10-50; has good antiviral synergistic effect, and can be used as potential medicine for resisting virus, especially hepatitis B virus.

Detailed Description

The following examples are provided to further understand the present invention, not to limit the scope of the present invention, but to provide the best mode, not to limit the content and the protection scope of the present invention, and any product similar or similar to the present invention, which is obtained by combining the present invention with other prior art features, falls within the protection scope of the present invention.