阅读说明：本技术 藻酸双酯钠在制备用于预防或***转移的药物中的应用 (Application of polysaccharide sulfate in preparation of medicine for preventing or treating tumor metastasis ) 是由 邱培菊 管华诗 杨金波 马赫 李春霞 王鑫 赵晨阳 于 2018-08-27 设计创作，主要内容包括：本发明提供了藻酸双酯钠在制备用于预防或治疗肿瘤转移的药物中的应用。藻酸双酯钠具有安全性较高,出血副作用较小的优点,藻酸双酯钠来源于海洋,原料易得,价格便宜。本发明通过实验进一步证明藻酸双酯钠具有抑制肿瘤肺转移和肝转移的作用,效果显著,本发明增加了藻酸双酯钠的临床适应症,弥补了抗肿瘤转移药物市场的不足,具有重要的经济和社会价值。(The invention provides application of polysaccharide sulfate in preparing a medicament for preventing or treating tumor metastasis. The polysaccharide sulphate has the advantages of high safety and small bleeding side effect, is sourced from oceans, is easy to obtain raw materials and is low in price. Experiments further prove that the polysaccharide sulphate has the effect of inhibiting tumor lung metastasis and liver metastasis, has obvious effect, increases the clinical indication of the polysaccharide sulphate, makes up the deficiency of the anti-tumor metastasis medicament market, and has important economic and social values.)

1. Use of sodium alginate diester in the preparation of a medicament for the prevention or treatment of tumour metastasis.

2. Use according to claim 1, characterized in that: the tumor metastasis is tumor lung metastasis or tumor liver metastasis.

3. Use according to claim 2, characterized in that: the tumor metastasis is lung metastasis of melanoma cells or liver metastasis of mast cell cancer cells.

4. Use according to claim 1, characterized in that: the sodium alginate diester inhibits tumor metastasis in a dose-dependent manner.

5. The application of polysaccharide sulfate in preparing the medicament is characterized in that: the medicament increases CD4 in a subject⁺And CD8⁺ Percentage of T cells.

6. The application of polysaccharide sulfate in preparing the medicament is characterized in that: the medicament increases CD4 in a subject⁺/CD8⁺Proportion of T cells.

7. Use according to claim 5 or 6, characterized in that: the CD4⁺And CD8⁺ T cells are CD4 in peripheral blood and/or in the mediastinal lymph nodes of the lung⁺And CD8⁺ T cells.

8. The application of polysaccharide sulfate in preparing the medicament is characterized in that: the drug inhibits adhesion between tumor cells and L-selectin.

9. Use according to claim 8, characterized in that: the sodium diester alginate inhibits adhesion between tumor cells and L-selectin in a dose-dependent manner.

10. Use according to any one of claims 1 to 9, characterized in that: the molecular weight of the polysaccharide sulphate is 1,000 Da-25,000 Da.

11. Use according to any one of claims 1 to 9, characterized in that: the administration mode of the medicine is intraperitoneal injection, intravenous injection or oral administration.