阅读说明：本技术 板蓝根吲哚醛在制备抗病毒药物中的应用 (Application of the Radix Isatidis indolal in preparation antiviral drugs ) 是由 杨子峰 李征途 李菁 李润峰 周红霞 李楚源 王德勤 于 2018-05-25 设计创作，主要内容包括：本发明提供了板蓝根吲哚醛在制备抗病毒药物中的应用,其中病毒为以下的任意一种：副流感病毒、单纯疱疹病毒、肠道病毒、鼻病毒、柯萨奇病毒。本发明提供的药物安全有效、毒副作用小。(The present invention provides Radix Isatidis indolal preparation antiviral drugs in application, wherein virus be it is below any one: parainfluenza virus, herpes simplex virus, enterovirus, rhinovirus, Coxsackie virus.Drug provided by the invention is safe and effective, toxic side effect is small.)

1. application of the Radix Isatidis indolal in preparation antiviral drugs, which is characterized in that the virus is below any one Kind: parainfluenza virus, herpes simplex virus, enterovirus, rhinovirus, Coxsackie virus.

2. application according to claim 1, which is characterized in that the Radix Isatidis indolal is extracted from Radix Isatidis.

3. application according to claim 1, it is characterised in that: the drug is tablet or capsule.

4. the application in the drug of filial generation duplication of the Radix Isatidis indolal in preparation for inhibiting virus, which is characterized in that described Virus be it is below any one: parainfluenza virus, herpes simplex virus, enterovirus, rhinovirus, Coxsackie virus.

5. application according to claim 4, which is characterized in that the Radix Isatidis indolal is extracted from Radix Isatidis.

6. application according to claim 4, it is characterised in that: the drug is tablet or capsule.

Technical field

The invention belongs to biomedicine fields, more particularly to Radix Isatidis indolal answering in preparation antiviral drugs With.

Background technique

Infectious diseases caused by virus seriously threatens always the life and health of the mankind.According to statistics, 80% or more Infectious disease be caused by virus.And most commonly feel as caused by Respirovirus and enterovirus in virus infection Dye.Common virus includes Respiratory Syncytial Virus(RSV) (RSV)；Parainfluenza virus (PIV3)；Adenovirus (ADV)；Herpes simplex virus (HSV-1,HSV-2)；Enterovirus (EV71)；Rhinovirus (HRV)；Coxsackie virus (CoxA16).Respiratory Syncytial Virus(RSV) is The most important pathogeny of respiratory tract infection of infants, while being also the master of the elderly and immune deficiency crowd's lower respiratory tract infection Factor is wanted, there is no effective vaccine and the therapeutic agent specifically for respiratory syncytial virus infection at present；Human parainfluenza virus (PIVs) usually cause a kind of virus of children's lower respiratory tract infection, it is pathogenic to be only second to Respiratory Syncytial Virus(RSV) (RSV)；Gland Virus infection, which is broken out, to happen occasionally, and induced Acute respiratory tract infection infectiousness is strong, and epidemic situation development is fast, and some cases are in a bad way, It is the common virus for causing childrens respiratory tract infection, wherein adenovirus pneumonia is the serious types of infantile pneumonia, while adenopathy Malicious infectiousness is very strong, especially in densely populated place, passes through droplet and contact more infectivity to the patient of hypoimmunity. Therefore its harm can not be ignored.Human simple blister blight poison is divided into amphitypy, 1 type and 2 types.1 type mainly causes genitals with crust The infection of skin, mucous membrane oral mucosa and organ brain.2 types then mainly cause genital area mucocutaneous infections.Genitals blister epidemic disease It is the disease that spreads through sex intercourse based on causing, disease incidence is high, can infect newborn by placenta and birth canal, cause miscarriage or newborn dead It dies, it is also related with the generation of cervical carcinoma.Rhinovirus picornavirus can not only cause common cold, moreover it is possible to cause it is anxious, Other infectious disease of respiratory system such as chronic bronchitis, it is especially more close with the onset relation of childhood asthma.Coxsack disease Poison belongs to Picornaviridae, enterovirus genus.Mainly infected via fecal-oral route.Coxsackie virus can cause popular chest Bitterly, the main pathogens of aseptic isolator, meningoencephalitis and pericarditis, especially vital myocarditis can cause cardiac muscular tissue Focal necrosis occurs, and with inflammatory cell infiltration, the pathological changes persistent viral infection such as cardiac muscle cell's cracking can lead to expansion Property cardiomyopathy.According to statistics, the annual myocarditis illness rate in the whole world is a ten thousand, and acute pericarditis patient, acute myocarditis patient have Recent or recurrence infection.Due to lacking effective therapeutic agent, many patients develop into chronic expanding cardiomyopathy, last dead In heart failure.Since Coxsackie virus is typical molten cell virus, it there is no ideal effective chemicals at present.

Since 20 generations in centurial year, many new antiviral drugs of researcher's discovery, that clinically applies at present is disease-resistant Cytotoxic drug more than has been more than, but then there are still very big disputes for its definite curative effect.Because virus is that parasitic host is intracellular, it is ensured that anti- The drug of virus has high selectivity, should can enter cell, selectively the reproduction process of effective viral interference, keeps away again Exempt to injure host cell, this is that have that selectivity is high in antiviral especially Respirovirus Western medicine and that toxic side effect is high is main more Reason.And after antiviral chemical synthesis class long term combined use, virus easily generates drug resistance to it, has become and has clinically controlled Treat the thorny problem of viral disease.So antiviral drugs research have important practical significance, find efficiently, safety, The research of the antiviral drugs of few side effects is imperative.

Summary of the invention

The purpose of the present invention is aiming at the above technical problems to be solved, provide a kind of safety and low toxicity to be efficiently used to treat The drug of common virus infectious disease.

For this purpose, the application the present invention provides Radix Isatidis indolal in preparation antiviral drugs, wherein the virus is It is below any one: parainfluenza virus (PIV3), herpes simplex virus (HSV-1, HSV-2), enterovirus (EV71), rhinopathy Poison (HRV), Coxsackie virus (CoxXB3).

Radix Isatidis indolal of the invention separates preferably from Radix Isatidis and purification obtains, structural formula are as follows:

The present invention also provides Radix Isatidis indolal in preparation for inhibiting the filial generation duplication of virus (virus to be inhibited to increase Grow) drug in application, wherein it is described virus be it is below any one: parainfluenza virus (PIV3), herpes simplex virus (HSV-1, HSV-2), enterovirus (EV71), rhinovirus (HRV), Coxsackie virus (CoxXB3).

Further, the Radix Isatidis indolal is extracted from Radix Isatidis.

Further, the drug can be made into any dosage form pharmaceutically allowed, and dosage form is such as, but not limited to tablet, glue Capsule etc..

The experimental results showed that the present invention provides it is a kind of safely and effectively, toxic side effect it is small for treating clinical wide spectrum disease The drug of viral disease.

Specific embodiment

To be best understood from the present invention, the content of present invention is described further combined with specific embodiments below, but the present invention Protection content be not limited to following instance.