阅读说明：本技术 检测位于生物全血中血细胞外侧的至少一种核酸的体外方法以及用于该目的的装置和试剂盒 (In vitro method for detecting at least one nucleic acid located outside blood cells in biological whole blood, and device and kit for this purpose ) 是由 拉尔夫·希默尔赖希 伯里克利·西蒙 于 2019-12-18 设计创作，主要内容包括：本发明涉及一种用于检测位于生物全血中血细胞外侧的至少一种核酸(优选DNA和/或RNA,特别优选DNA)的体外方法、装置和试剂盒。根据本发明的方法的优点在于,与现有技术中的已知方法相比,实施该方法需要更少的时间和装置工作,并且使污染的风险和待扩增的无细胞核酸(例如,无细胞DNA)损失的风险最小化。因此,该方法比已知的无细胞核酸(例如,无细胞DNA)检测方法更经济且具有更高的检测精度。此外,与基于全血稀释的现有技术的检测方法相比,检测灵敏度首先得到提高。此外,提出使用提供的装置和提供的试剂盒。(The present invention relates to an in vitro method, device and kit for detecting at least one nucleic acid, preferably DNA and/or RNA, particularly preferably DNA, located outside blood cells in biological whole blood. The advantage of the method according to the invention is that it requires less time and equipment work to carry out the method compared to the methods known in the prior art and minimizes the risk of contamination and the risk of loss of cell-free nucleic acid (e.g. cell-free DNA) to be amplified. Thus, the method is more economical and has higher detection accuracy than known cell-free nucleic acid (e.g., cell-free DNA) detection methods. Furthermore, the detection sensitivity is first improved compared to the prior art detection methods based on whole blood dilution. Furthermore, it is proposed to use the provided device and the provided kit.)