阅读说明：本技术 新的锌络合物、其产生及用途 (Novel zinc complexes, their production and use ) 是由 弗拉迪米尔·叶夫根尼耶维奇·涅博利辛 于 2019-08-22 设计创作，主要内容包括：本发明涉及金属/配体比为1/1的新的γ-L-谷氨酰组胺的锌络合物。特别地,本发明涉及式(I)化合物。根据本发明的络合物促进上皮组织屏障功能的恢复并抑制免疫系统细胞的异常活性。本发明还涉及络合物的产生和所述锌络合物用于治疗特应性皮炎和与上皮组织的屏障功能破坏和异常炎性应答的发生相关的其他疾病的用途。本发明还涉及所获得的络合物用于抑制谷氨酰胺酰环化酶的用途。本发明还涉及包含治疗有效量的根据本发明的化合物的药物组合物。(The present invention relates to a novel zinc complex of gamma-L-glutamyl histamine having a metal/ligand ratio of 1/1. In particular, the present invention relates to compounds of formula (I). The complexes according to the invention promote the restoration of the barrier function of epithelial tissues and inhibit the cells of the immune systemThe abnormal activity of (2). The invention also relates to the production of the complexes and the use of said zinc complexes for the treatment of atopic dermatitis and other diseases associated with the breakdown of the barrier function of epithelial tissues and the development of abnormal inflammatory responses. The invention also relates to the use of the obtained complex for inhibiting glutaminyl cyclase. The invention also relates to pharmaceutical compositions comprising a therapeutically effective amount of a compound according to the invention.)