阅读说明：本技术 一种左乙拉西坦的制备方法 (Preparation method of levetiracetam ) 是由 潘洪杰 龚玉龙 朱坤 肖延铭 张文灵 王鹏 于 2017-08-08 设计创作，主要内容包括：提供一种左乙拉西坦的制备方法，该方法以2?溴丁酸酯和2?吡咯烷酮为原料，在碱性试剂作用下生成(R/S)?α?乙基?2?氧代?1?吡咯烷乙酸酯；在酯水解酶作用下拆分获得(S)?α?乙基?2?氧代?1?吡咯烷乙酸酯；最后通过氨解得到左乙拉西坦。原料易得，操作简单，收率高，非常有利于工业化生产的要求。(The preparation method of levetiracetam is characterized by using 2-bromobutanoate and 2-pyrrolidone as raw materials, generating (R/S) - α -ethyl-2-oxo-1-pyrrolidine acetate under the action of an alkaline reagent, obtaining (S) - α -ethyl-2-oxo-1-pyrrolidine acetate through resolution under the action of ester hydrolase, and finally obtaining levetiracetam through ammonolysis.)