阅读说明：本技术 一种左乙拉西坦的合成方法 (Synthesis method of levetiracetam ) 是由 潘洪杰 肖延铭 张文灵 王鹏 于 2017-08-08 设计创作，主要内容包括：公开了一种左乙拉西坦的制备方法,其包括以下步骤：以2-卤代丁酸酯为原料,在酯水解酶作用下拆分获得(S)-2-卤代丁酸酯；再与2-吡咯烷酮在碱性试剂作用下生成(S)-α-乙基-2-氧代-1-吡咯烷乙酸酯；最后氨解得到左乙拉西坦。该方法工艺操作简单,原料易得,环境污染小,产品的HPLC纯度和光学纯度高,非常适合用于工业生产。(The preparation process of levetiracetam includes the steps of splitting 2-halobutyrate as material under the action of ester hydrolase to obtain (S) -2-halobutyrate, reacting with 2-pyrrolidone under the action of alkali reagent to produce (S) - α -ethyl-2-oxo-1-pyrrolidine acetate, and final ammonolysis to obtain levetiracetam.)