阅读说明：本技术 血管生成素样3表达的调节 (Modulation of angiopoietin-like 3 expression ) 是由 R·M·克鲁克 M·J·格雷厄姆 R·李 K·W·多比 于 2011-01-07 设计创作，主要内容包括：本文提供的是用于减少动物中ANGPTL3 mRNA和蛋白的表达的方法、化合物和组合物。本文还提供的是用于在动物中减少血浆脂质、血浆葡萄糖和动脉粥样硬化斑块的方法、化合物和组合物。此类方法、化合物和组合物可用于治疗、预防、延缓或减轻任何一种或多种心血管疾病或代谢疾病或其症状。(Provided herein are methods, compounds, and compositions for reducing expression of ANGPTL3mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose, and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful for treating, preventing, delaying, or ameliorating any one or more cardiovascular diseases or metabolic diseases or symptoms thereof.)